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Weirui Guo
Researcher at University of Texas Southwestern Medical Center
Publications - 10
Citations - 1227
Weirui Guo is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Fragile X syndrome & FMR1. The author has an hindex of 9, co-authored 9 publications receiving 1088 citations. Previous affiliations of Weirui Guo include Chinese Academy of Sciences & Northwestern University.
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Journal ArticleDOI
An ALS-associated Mutation Affecting TDP-43 Enhances Protein Aggregation, Fibril Formation and Neurotoxicity
Weirui Guo,Yanbo Chen,Xiaohong Zhou,Amar N. Kar,Amar N. Kar,Payal Ray,Xiaoping Chen,Elizabeth J. Rao,Mengxue Yang,Haihong Ye,Li Zhu,Jianghong Liu,Meng Xu,Yanlian Yang,Chen Wang,David Luowei Zhang,Eileen H. Bigio,M.-Marsel Mesulam,Yan Shen,Qi Xu,Kazuo Fushimi,Jane Y. Wu +21 more
TL;DR: Comparing wild-type and an ALS-associated mutant TDP-43 in vitro and in vivo provides evidence for biochemical similarities between TPD-43 and prion proteins, raising the possibility that T DP-43 derivatives may cause spreading of the disease phenotype among neighboring neurons.
Journal ArticleDOI
A Drosophila model for TDP-43 proteinopathy
Yan Li,Payal Ray,Elizabeth J. Rao,Chen Shi,Chen Shi,Weirui Guo,Xiaoping Chen,Elvin A. Woodruff,Kazuo Fushimi,Jane Y. Wu +9 more
TL;DR: Transgenic flies expressing hTDP-43 recapitulate important neuropathological and clinical features of human TDP- 43 proteinopathy, providing a powerful animal model for this group of devastating diseases.
Journal ArticleDOI
Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
Nien Pei Tsai,Julia Wilkerson,Weirui Guo,Marina A. Maksimova,George N. DeMartino,Christopher W. Cowan,Christopher W. Cowan,Kimberly M. Huber +7 more
TL;DR: It is reported here that protocadherin 10 (Pcdh10), an autism-spectrum disorders gene, is necessary for this process and roles for multiple autism-linked genes in activity-dependent synapse elimination are revealed.
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Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
Jennifer A. Ronesi,Katie A. Collins,Seth A. Hays,Nien Pei Tsai,Weirui Guo,Shari G. Birnbaum,Jia Hua Hu,Paul F. Worley,Jay R. Gibson,Kimberly M. Huber +9 more
TL;DR: Findings reveal new functions for mGluR5-Homer interactions in the brain and delineate distinct mechanisms of mGLUR5 dysfunction in a mouse model of cognitive dysfunction and autism.
Journal ArticleDOI
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice
Kristen K. Ade,Yehong Wan,Harold C. Hamann,Justin K. O’Hare,Weirui Guo,Anna Quian,Sunil Kumar,Srishti Bhagat,Ramona M. Rodriguiz,William C. Wetsel,P. Jeffrey Conn,P. Jeffrey Conn,Kafui Dzirasa,Kimberly M. Huber,Nicole Calakos +14 more
TL;DR: A causal role for increased mGluR5 signaling in driving striatal output abnormalities and behaviors with relevance to OCD is demonstrated and the tractability of acute mGLUR5 inhibition to remedy circuit and behavioral abnormalities is shown.