Payam Rezaie

TL;DR: The view that microglia are derived prenatally from mesodermal progenitors that are distinct from monocytes is supported and new hypotheses in the light of emerging data suggest clear differences between fetal and adult ontogeny of myeloid cells.

TL;DR: Current concepts on the pathogenesis of PVL are presented and the increasing evidence for an inflammatory pathogenic component to this disorder, either resulting from hypoxic‐ischemic injury or from infection is emphasized.

TL;DR: Large loss of neurons was observed at sites of Abeta aggregation and surrounding astrocytes but, most importantly, was also clearly observed in areas of the parenchyma distant from plaques, pointing to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease.

TL;DR: The elevated expression of CCR2, CCR3 and CCR5 in the CNS in MS suggests these beta-chemokine receptors and their ligands play a role in the pathogenesis of MS.

TL;DR: The phenotype and functional characteristics of fetal microglia are outlined in this review, and the need for specific cellular interactions and targeting is greater within the central nervous system than in other tissues.