D
David Male
Researcher at Open University
Publications - 111
Citations - 6126
David Male is an academic researcher from Open University. The author has contributed to research in topics: Endothelium & Blood–brain barrier. The author has an hindex of 36, co-authored 111 publications receiving 5634 citations.
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Journal ArticleDOI
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
Babette B. Weksler,E. A. Subileau,N. Perrière,Pierre Charneau,Karen Holloway,Mathilde Leveque,H. Tricoire-Leignel,A. Nicotra,Sandrine Bourdoulous,Patric Turowski,David Male,Françoise Roux,John Greenwood,Ignacio A. Romero,P.O. Couraud +14 more
TL;DR: In this article, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen, and one was selected for expression of normal endothelial markers, including CD31, VE cadherin, and von Willebrand factor.
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MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation
Miguel Alejandro Lopez-Ramirez,Dongsheng Wu,Gareth Pryce,Julie E. Simpson,Arie Reijerkerk,Josh King-Robson,Oliver Kay,Helga E. de Vries,Mark C. Hirst,Basil Sharrack,David Baker,David Male,Gregory J. Michael,Ignacio A. Romero +13 more
TL;DR: It is proposed that brain endothelial miR‐155 is a negative regulator of BBB function that may constitute a novel therapeutic target for CNS neuroinflammatory disorders.
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Expression of the β-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue
TL;DR: The elevated expression of CCR2, CCR3 and CCR5 in the CNS in MS suggests these beta-chemokine receptors and their ligands play a role in the pathogenesis of MS.
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Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues.
Lance Hudson,Jiankai Liu,Avindra Nath,Melina Jones,Ravi Raghavan,Opendra Narayan,David Male,Ian P. Everall +7 more
TL;DR: The role of Tat is detected immunohistochemically and in protein extracts from the brains of rhesus macaques with encephalitis due to a chimeric strain of HIV and simian immunodeficiency virus (SHIV).
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Regulation of chemokine receptor expression in human microglia and astrocytes.
TL;DR: The data indicates a mechanism by which activated microglia and astrocytes become selectively more sensitive to inflammatory chemokines during CNS disease, and the paper discusses which of the many Chemokines present in CNS would have priority of action on microglial cells and astracytes.