Peggy S. Eis

TL;DR: It is found that clinical isolates of several types of B cell lymphomas, including diffuse large B Cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells, and the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of mi R-155 is controlled by transcription and processing.

TL;DR: Using oligonucleotide arrays, the breakpoints of this microdeletion were refined, defining a 478-kb critical region containing six genes that were deleted in all four individuals, and it was found that these breakpoint regions are sites of copy number polymorphism in controls, indicating that these may be inherently unstable genomic regions.

TL;DR: The invasive signal amplification reaction is described as a method that couples two invasive reactions into a serial isothermal homogeneous assay using fluorescence resonance energy transfer detection and a simple kinetic model of the assay is described.

TL;DR: It is demonstrated that oligonucleotide array CGH (oaCGH) analysis can routinely map chromosomal imbalance breakpoints at exon‐level resolution, including imbalances that are single copy number genomic alterations.

TL;DR: The use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes.