J
Jacqueline E. Payton
Researcher at Washington University in St. Louis
Publications - 86
Citations - 16607
Jacqueline E. Payton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 34, co-authored 79 publications receiving 14672 citations. Previous affiliations of Jacqueline E. Payton include University of Illinois at Urbana–Champaign & Barnes-Jewish Hospital.
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Journal ArticleDOI
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Timothy J. Ley,Christopher A. Miller,Li Ding,Benjamin J. Raphael,Andrew J. Mungall,Gordon Robertson,Katherine A. Hoadley,Timothy J. Triche,Peter W. Laird,Jack Baty,Lucinda Fulton,Robert S. Fulton,Sharon Heath,Joelle Kalicki-Veizer,Cyriac Kandoth,Jeffery M. Klco,Daniel C. Koboldt,Krishna L. Kanchi,Shashikant Kulkarni,Tamara Lamprecht,David E. Larson,G. Lin,Charles Lu,Michael D. McLellan,Joshua F. McMichael,Jacqueline E. Payton,Heather Schmidt,David H. Spencer,Michael H. Tomasson,John W. Wallis,Lukas D. Wartman,Mark A. Watson,John S. Welch,Michael C. Wendl,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Readman Chiu,Andy Chu,Eric Chuah,Hye Jung E. Chun,Richard Corbett,Noreen Dhalla,Ranabir Guin,An He,Carrie Hirst,Martin Hirst,Robert A. Holt,Steven J.M. Jones,Aly Karsan,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Karen Mungall,Jeremy Parker,Erin Pleasance,Patrick Plettner,Jacquie Schein,Dominik Stoll,Lucas Swanson,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Stacey Gabriel,Gad Getz,Carrie Sougnez,Lihua Zou,Mark D.M. Leiserson,Fabio Vandin,Hsin-Ta Wu,Frederick Applebaum,Stephen B. Baylin,Rehan Akbani,Bradley M. Broom,Ken Chen,Thomas C. Motter,Khanh Thi-Thuy Nguyen,John N. Weinstein,Nianziang Zhang,Martin L. Ferguson,Christopher Adams,Aaron D. Black,Jay Bowen,Julie M. Gastier-Foster,Thomas Grossman,Tara M. Lichtenberg,Lisa Wise,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Margi Sheth,Heidi J. Sofia,Liming Yang,James R. Downing,Greg Eley,Shelley Alonso,Brenda Ayala,Julien Baboud,Mark Backus,Sean P. Barletta,Dominique L. Berton,Anna L. Chu,Stanley Girshik,Mark A. Jensen,Ari B. Kahn,Prachi Kothiyal,Matthew C. Nicholls,Todd Pihl,David Pot,Rohini Raman,Rashmi N. Sanbhadti,Eric E. Snyder,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Zhining Wang,Jean Pierre J. Issa,Michelle M. Le Beau,Martin Carroll,Hagop M. Kantarjian,Steven M. Kornblau,Moiz S. Bootwalla,Phillip H. Lai,Hui Shen,David Van Den Berg,Daniel J. Weisenberger,Daniel C. Link,Matthew J. Walter,Bradley A. Ozenberger,Elaine R. Mardis,Peter Westervelt,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +138 more
TL;DR: It is found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients and the databases from this study are widely available to serve as a foundation for further investigations of AMl pathogenesis, classification, and risk stratification.
Journal ArticleDOI
Recurring mutations found by sequencing an acute myeloid leukemia genome.
Elaine R. Mardis,Li Ding,David J. Dooling,David E. Larson,Michael D. McLellan,Ken Chen,Daniel C. Koboldt,Robert S. Fulton,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Devin P. Locke,Vincent Magrini,Rachel Abbott,Tammi L. Vickery,Jerry S. Reed,Jody S. Robinson,Todd Wylie,Scott M. Smith,Lynn K. Carmichael,James M. Eldred,Chris Harris,Jason Walker,Joshua Peck,Feiyu Du,Adam F. Dukes,Gabriel E. Sanderson,Anthony M. Brummett,Eric M. Clark,Joshua F. McMichael,Rick Meyer,Jonathan K. Schindler,Craig Pohl,John W. Wallis,Xiaoqi Shi,Ling Lin,Heather Schmidt,Yuzhu Tang,Carrie A. Haipek,Madeline E. Wiechert,Jolynda V. Ivy,Joelle Kalicki,Glendoria Elliott,Rhonda E. Ries,Jacqueline E. Payton,Peter Westervelt,Michael H. Tomasson,Mark A. Watson,Jack Baty,Sharon Heath,William D. Shannon,Rakesh Nagarajan,Daniel C. Link,Matthew J. Walter,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson,Timothy J. Ley +57 more
TL;DR: By comparing the sequences of tumor and skin genomes of a patient with AML-M1, recurring mutations that may be relevant for pathogenesis are identified.
Journal ArticleDOI
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Li Ding,Timothy J. Ley,David E. Larson,Christopher A. Miller,Daniel C. Koboldt,John S. Welch,Julie Ritchey,Margaret A. Young,Tamara Lamprecht,Michael D. McLellan,Joshua F. McMichael,John W. Wallis,Charles Lu,Dong Shen,Chris Harris,David J. Dooling,Robert S. Fulton,Lucinda Fulton,Ken Chen,Heather Schmidt,Joelle Kalicki-Veizer,Vincent Magrini,Lisa Cook,Sean McGrath,Tammi L. Vickery,Michael C. Wendl,Sharon Heath,Mark A. Watson,Daniel C. Link,Michael H. Tomasson,William D. Shannon,Jacqueline E. Payton,Shashikant Kulkarni,Peter Westervelt,Matthew J. Walter,Timothy A. Graubert,Elaine R. Mardis,Richard K. Wilson,John F. DiPersio +38 more
TL;DR: The sequenced primary tumour and relapse genomes from eight AML patients and validated hundreds of somatic mutations using deep sequencing demonstrated that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped by the chemotherapy that the patients receive to establish and maintain remissions.
Journal ArticleDOI
DNMT3A Mutations in Acute Myeloid Leukemia
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,R. Reid Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: DNMT3A mutations are highly recurrent in patients with de novo AML with an intermediate-risk cytogenetic profile and are independently associated with a poor outcome in Cox proportional-hazards analysis.
Journal ArticleDOI
The origin and evolution of mutations in acute myeloid leukemia.
John S. Welch,Timothy J. Ley,Daniel C. Link,Christopher A. Miller,David E. Larson,Daniel C. Koboldt,Lukas D. Wartman,Tamara Lamprecht,Fulu Liu,Jun Xia,Cyriac Kandoth,Robert S. Fulton,Michael D. McLellan,David J. Dooling,John W. Wallis,Ken Chen,Chris Harris,Heather Schmidt,Joelle Kalicki-Veizer,Charles Lu,Qunyuan Zhang,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Lucinda Fulton,Vincent Magrini,Sean McGrath,Ryan Demeter,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Jacqueline E. Payton,Jack Baty,Shashikant Kulkarni,Jeffery M. Klco,Michael H. Tomasson,Peter Westervelt,Matthew J. Walter,Timothy A. Graubert,John F. DiPersio,Li Ding,Elaine R. Mardis,Richard K. Wilson +53 more
TL;DR: The data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is "captured" as the clone expands.