Pei-Hua Peng

TL;DR: It is reported that mammalian mitochondrial DNA (mtDNA) is enriched for 6mA, which is at least 1,300-fold higher than that in gDNA under normal growth conditions, corresponding to approximately four 6mA modifications on each mtDNA molecule.

TL;DR: It is demonstrated that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1α and is essential for Hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.

TL;DR: The role of liquid-liquid phase separation (LLPS) in regulating normal cellular physiology and contributing to tumorigenesis is discussed in this paper, where the authors summarize the principle and components of LLPS, and describe how LLPS regulate these numerous biological processes and how disruption of the LLPS would cause disease formation.

TL;DR: The review aims to identify suitable lncRNAs that may provide feasible therapeutic venues for hypoxia-involved cancers and the role of a recently discovered lncRNA RP11-390F4.3 in hypoxIA-induced EMT is discussed.

TL;DR: In this paper, the authors used ATAC-seq and RNA-seq to identify GSTM1 (glutathione S-transferase mu-1) as a prognostic marker of GBM patient survival.