N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
Ziyang Hao,Tong Wu,Xiaolong Cui,Pingping Zhu,Cai-Ping Tan,Xiaoyang Dou,Kai-Wen Hsu,Yueh-Te Lin,Pei-Hua Peng,Li-Sheng Zhang,Yawei Gao,Lulu Hu,Hui-Lung Sun,Allen C. Zhu,Jianzhao Liu,Kou-Juey Wu,Chuan He +16 more
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TLDR
It is reported that mammalian mitochondrial DNA (mtDNA) is enriched for 6mA, which is at least 1,300-fold higher than that in gDNA under normal growth conditions, corresponding to approximately four 6mA modifications on each mtDNA molecule.About:
This article is published in Molecular Cell.The article was published on 2020-03-16 and is currently open access. It has received 133 citations till now. The article focuses on the topics: Mitochondrial DNA & DNA methylation.read more
Citations
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Journal ArticleDOI
Mapping the epigenetic modifications of DNA and RNA
TL;DR: Third-generation sequencing methods are summarized, which enable long-read and single-molecule sequencing of DNA and RNA modification and discuss questions to be addressed.
Journal ArticleDOI
The language of chromatin modification in human cancers.
TL;DR: In this article, it is shown that miswriting, misreading or mis-erasing of the modification language embedded in chromatin represents a common, sometimes early and pivotal, event across a wide range of human cancers, contributing to oncogenesis through the induction of epigenetic, transcriptomic and phenotypic alterations.
Journal ArticleDOI
Extreme heterogeneity of human mitochondrial DNA from organelles to populations.
TL;DR: These findings cast light on the origin and spread of mtDNA mutations at multiple scales, from the organelle to the human population, and challenge the conventional view that high percentages of a mutation are required before a new variant has functional consequences.
Journal ArticleDOI
Visible-Light-Mediated Modification and Manipulation of Biomacromolecules.
Vivian M. Lechner,Manuel Nappi,Patrick J. Deneny,Sarah Folliet,John C. K. Chu,Matthew J. Gaunt +5 more
TL;DR: In this paper, the authors discuss modifications of native functional groups (FGs), including functionalization, labeling, and cross-linking techniques as well as the utility of oxidative degradation mediated by photochemically generated reactive oxygen species.
Journal ArticleDOI
Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.
TL;DR: The current principles of splicing regulation are summarized, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications.
References
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.
Michael Weber,Ines Hellmann,Michael B. Stadler,Liliana Ramos,Svante Pääbo,Michael Rebhan,Dirk Schübeler +6 more
TL;DR: Results show that promoter sequence and gene function are major predictors of promoter methylation states and that inactive unmethylated CpG island promoters show elevated levels of dimethylation of Lys4 of histone H3, suggesting that this chromatin mark may protect DNA from methylation.
Journal ArticleDOI
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Jianzhao Liu,Yanan Yue,Dali Han,Xiao Wang,Ye Fu,Liang Zhang,Guifang Jia,Miao Yu,Zhike Lu,Xin Deng,Qing Dai,Weizhong Chen,Chuan He +12 more
TL;DR: It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs.
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