Cai-Ping Tan

TL;DR: In this article, four cyclometalated iridium(III)-β-carboline complexes with pH-responsive singlet oxygen (1O2) production and lysosome-specific imaging properties have been designed and synthesized.

TL;DR: It is demonstrated that a series of ruthenium(II) complexes containing a β-carboline alkaloid as ligand can simultaneously induce autophagy and apoptosis in tumor cells, and suppression ofautophagy using pharmacological inhibitors enhances apoptotic cell death.

TL;DR: Mechanism studies show that these complexes exert their anticancer efficacy by initiating a cascade of events related to mitochondrial dysfunction, and display up to 3 orders of magnitude higher cytotoxicity upon irradiation at 365 nm, which is so far the highest photocytotoxic responses reported for iridium complexes.

TL;DR: It has been found that the extension of the N-N ligands can increase the stability of the complexes and the in vitro anticancer activities of these compounds are moderate on the five human cancer cell lines screened.

TL;DR: Two CdSe/ZnSe QDs modified with β-CD coupled to L-Arg or L-His were used to simultaneously deliver doxorubicin (Dox) and siRNA targeting the MDR1 gene to reverse the multidrug resistance of HeLa cells.