Pei-Zhuo Zhang

TL;DR: Clear evidence is shown that the micelleplex is capable of delivering siRNA and paclitaxel simultaneously to the same tumoral cells both in vitro and in vivo and can induce a synergistic tumor suppression effect in the MDA-MB-435s xenograft murine model.

TL;DR: Without exhibiting cellular toxicity, PEI-capped AuNPs appear to be suitable as a potential carrier for intracellular siRNA delivery.

TL;DR: A micelleplex system based on an amphiphilic and cationic triblock copolymer, which can systemically deliver siRNA targeting the acid ceramidase (AC) gene for cancer therapy, and is found to induce remarkable apoptosis and reduce the proliferation of cancer cells.

TL;DR: A PEGylated LPH nanoparticle formulation modified with cyclic RGD peptide (cRGD) for specific and efficient delivery of AMO into endothelial cells, targeting α(v)β₃ integrin present on the tumor neovasculature is reported.

TL;DR: Systemic delivery of micellar nanoparticles containing small interfering RNA targeting CDK4 significantly inhibited tumor growth in an A549 NSCLC xenograft murine model, suggesting the therapeutic promise of MNPsiCDK4 delivery in KRAS mutant NSCLCs via a synthetic lethal interaction between KRAS and CDK 4.