Peng Gao

TL;DR: It is found that RGPs progress through a coherent program in which their proliferative potential diminishes in a predictable manner, suggesting that progenitor behavior and histogenesis in the mammalian neocortex conform to a remarkably orderly and deterministic program.

TL;DR: It is shown that clonally related excitatory neurons in the developing hippocampus are progressively organized into discrete horizontal, but not vertical, clusters in the stratum pyramidale, as revealed by both cell-type-specific retroviral labeling and mosaic analysis with double markers (MADM).

TL;DR: Findings are beginning to reveal how individual components of circuits are generated and assembled during development, and how early developmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.

TL;DR: It is shown that TBR2 regulates fine-scale spatial and circuit organization of excitatory neurons in addition to enhancing neurogenesis in the mouse cortex and PCDH19 directly regulates the expression of Protocadherin 19 (PCDH19), and simultaneous PC DH19 expression rescues neurogenisation and neuronal organization defects caused by TBR1 removal.

TL;DR: This chapter discusses the formation of neocortical circuits, emphasizing on how individual components are generated and assembled during development and how early developmental processes, including neurogenesis and neuronal migration, may guide precise circuit assembly.