Peng Zheng

TL;DR: It is demonstrated that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host’s metabolism.

TL;DR: It is found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs), and the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology.

TL;DR: NMR-based plasma metabonomics may offer an accurate empirical laboratory-based method applicable to the diagnosis of MDD.

TL;DR: It is demonstrated that this urinary metabolite biomarker panel was capable of distinguishing depressed subjects from healthy controls with an area under the receiver operating characteristic curve (AUC) of 0.81 and can aid in the future development of a urine-based diagnostic test for MDD.

TL;DR: It is demonstrated that there were sex differences in gut microbiota in patients with MDD, and the suitability of Actinobacteria and Bacteroidia as the sex-specific biomarkers for diagnosing MDD should be further explored.