Peter Goldstraw

TL;DR: Recurrent somatic missense mutations at alanine 146, a highly conserved residue in the guanine nucleotide binding domain, are identified, suggesting that the contribution of codon 146 mutations is not entirely restricted to colorectal cancers or to KRAS.

TL;DR: Patients that underwent pulmonary resection at the Royal Brompton Hospital between 1991 and 1997 were included and the case notes of all patients developing postoperative complications were retrospectively reviewed.

TL;DR: Activated alveolar epithelium is an important source of chemokines that orchestrate leukocyte migration to the peripheral lung; early release of TNF-α and IL-1β by stimulated macrophages may contribute to alveolars epithelial cell activation and chemokine production.

TL;DR: Assessment of the ability of high resolution computed tomography to predict the histological appearance of open lung biopsy specimens from patients with systemic sclerosis found a significant association between a fibrotic Histological appearance and a grade 4 computed tomogram, and between an inflammatory histological appearances and a level 3 computed tomograms.

TL;DR: An extensive analysis has produced stage classification proposals for lung cancer with a robust degree of discriminatory consistency and general applicability and external validation is encouraged to identify areas of strength and weakness.