P
Peter I. Mackenzie
Researcher at Flinders University
Publications - 173
Citations - 13800
Peter I. Mackenzie is an academic researcher from Flinders University. The author has contributed to research in topics: Glucuronidation & Glucuronosyltransferase. The author has an hindex of 61, co-authored 170 publications receiving 12936 citations. Previous affiliations of Peter I. Mackenzie include Flinders Medical Centre & University of Western Australia.
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Journal ArticleDOI
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Peter I. Mackenzie,Ida S. Owens,Brian Burchell,Karl Walter Bock,Amos Marc Bairoch,Alain Bélanger,Sylvie Fournel-Gigleux,Mitchell D. Green,Dean W. Hum,Takashi Iyanagi,Doron Lancet,Pierre Louisot,Jacques Magdalou,Jayanla Roy Chowdhury,Joseph K. Ritter,Harry Schachter,Thomas R. Tephly,Keith F. Tipton,Daniel W. Nebert +18 more
TL;DR: This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution and is anticipated that this UGT gene nomenClature system will require updating on a regular basis.
Journal ArticleDOI
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Peter I. Mackenzie,Karl Walter Bock,Brian Burchell,Chantal Guillemette,Shinichi Ikushiro,Takashi Iyanagi,John O. Miners,Ida S. Owens,Daniel W. Nebert +8 more
TL;DR: The UGT nomenclature is updated to include new genes identified in the human, mouse and rat genomes and in other mammalian species to prevent confusion when the same gene is given different names.
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The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.
TL;DR: Recent advances in the understanding of the functional roles of UGT, their regulation and tissue expression, and clinical significant factors (ontogeny, interactions and polymorphisms) that affect glucuronidation activity in humans are discussed.
Journal ArticleDOI
Structural and functional studies of udp-glucuronosyltransferases*
TL;DR: Evidence from experiments on UGT interactions with inhibitors directed at specific amino acids, photoaffinity labeling, and analysis of amino acid alignments suggest that UDP-GIcUA interacts with residues in both the N- and C-terminal domains, whereas aglycon binding sites are localized in the N -terminal domain.
Journal ArticleDOI
Drug glucuronidation in humans.
TL;DR: Factors known to influence the pharmacokinetics of glucuronidated drugs in man, presumably via an effect on specific glucuronosyltransferases, include age, cigarette smoking, diet, certain disease states, coadministered drugs, ethnicity, genetics and hormonal effects.