P
Peter J. O'Brien
Researcher at University College Dublin
Publications - 318
Citations - 19961
Peter J. O'Brien is an academic researcher from University College Dublin. The author has contributed to research in topics: Glutathione & Cytotoxicity. The author has an hindex of 68, co-authored 316 publications receiving 18731 citations. Previous affiliations of Peter J. O'Brien include The Hertz Corporation & University of Toronto.
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Journal ArticleDOI
A-CD estrogens. I. substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds
James S. Wright,Hooman Shadnia,James M. Anderson,Tony Durst,Muhammad Asim,Mohamed El-Salfiti,Christine Choueiri,M.A. Christine Pratt,Samantha C. Ruddy,Rosanna Lau,Kathryn E. Carlson,John A. Katzenellenbogen,Peter J. O'Brien,Luke Wan +13 more
TL;DR: The synthesis, modeling, binding affinities, hormone potency, and a measure of quinone formation are described for a new family of A-CD estrogens, where the A-C bond is formed by ring coupling.
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The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
TL;DR: It was shown that pretreatment of mice with isosafrole also completely prevented ferric nitrilotriacetate (FeNTA)-induced renal necrosis and lipid peroxidation, even though metabolic activation by cytochrome P450 is not involved.
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Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes.
TL;DR: Comparisons of cytotoxic and toxicological properties of six dihydroxylated metabolites using isolated rat hepatocytes suggest that catecholic cytotoxicity can be attributed to mitochondrial toxicity and oxidative stress.
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Prooxidant activity and cytotoxic effects of indole-3-acetic acid derivative radicals.
TL;DR: It was found that the effectiveness of IAA analogues for catalyzing the cooxidation of ascorbate, NADH, or GSH increased as the IAA derivatives were more readily oxidized by HRP/H(2)O(2), which suggests that IAA skatole and/or (skatole) peroxyl radicals catalyze lipid peroxidation at pH 6.0.
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Compensatory up-regulation of cardiac SR Ca2+-pump by heat-shock counteracts SR Ca2+-channel activation by ischemia/reperfusion.
TL;DR: It is concluded that one of the mechanisms by which heat-shock protects myocardium from I/R injury is to upregulate SR Ca2+-pumping activity to counteract the enhanced SR Ca 2+-release produced by I/ R.