P
Peter J. O'Brien
Researcher at University College Dublin
Publications - 318
Citations - 19961
Peter J. O'Brien is an academic researcher from University College Dublin. The author has contributed to research in topics: Glutathione & Cytotoxicity. The author has an hindex of 68, co-authored 316 publications receiving 18731 citations. Previous affiliations of Peter J. O'Brien include The Hertz Corporation & University of Toronto.
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Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde.
TL;DR: Glycolaldehyde-caused hepatocyte protein carbonylation likely resulted from glyoxal, an autoxidation product formed by ROS, and hydroxypyruvate was found to be the most toxic fructose metabolite.
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Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes.
TL;DR: It is suggested that 3-HA is not suitable for treatment of melanoma and ring hydroxylation but not O-demethylation/epoxidation seems to be the bioactivation pathway for3-HA in rat liver.
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Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylation model)
TL;DR: The results suggest that bioactive almond skin constituents in the non-lipophilic polyphenol extract were the most effective at protecting hepatocytes against hydroperoxide induced hepatocyte oxidative stress and in protecting against dicarbonyl induced cytotoxicity.
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Best Practices for Clinical Pathology Testing in Carcinogenicity Studies
TL;DR: A Clinical Pathology in Carcinogenicity Studies Working Group recommends that clinical pathology testing be limited to collection of blood smears at scheduled and unscheduled sacrifices and to be examined only if indicated to aid in the diagnosis of possible hematopoietic neoplasia following histopathologic evaluation.
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Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs.
TL;DR: Testing the hypothesis that decreases in ATP-synthesis and Ca-release activities occurred earlier in the development of HF and persisted longer during recovery from HF found it to be true.