P
Peter J. O'Brien
Researcher at University College Dublin
Publications - 318
Citations - 19961
Peter J. O'Brien is an academic researcher from University College Dublin. The author has contributed to research in topics: Glutathione & Cytotoxicity. The author has an hindex of 68, co-authored 316 publications receiving 18731 citations. Previous affiliations of Peter J. O'Brien include The Hertz Corporation & University of Toronto.
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Journal ArticleDOI
Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity
TL;DR: It is demonstrated that acrolein was a more potent toxin than CAA for freshly isolated rat hepatocytes, bovine serum albumin and rat hepatic microsomes and the ability of protecting agents to protect against toxicities was dependent on its concentration.
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N-oxidation of aromatic amines by intracellular oxidases.
TL;DR: It was found that the prooxidant activity of the aromatic amine increased as its redox potential decreased with o-anisidine and aminofluorene being the most effective at forming reactive oxygen species, which suggests that the rate-limiting step in the cooxidation is the rate of arylamine oxidation by the peroxidase.
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Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration
TL;DR: The results suggest that P-450IIE1 catalyses the cytotoxic activation of CCl4, DMN, BB and naphthalene but not of lactonitrile or cyclophosphamide, and the administration of DEDC and its metabolites, disulfiram or CS2, inactivates P- 450IIE 1 so that the hepatocytes become resistant to these hepatotoxins.
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Respiratory chain defect of myocardial mitochondria in idiopathic dilated cardiomyopathy of Doberman pinscher dogs.
Laura Jill McCutcheon,Colin Robert Cory,Linda M. Nowack,Hua Shen,Medhi Mirsalami,Rudolf Lahucky,Lubomir Kovac,Michael R. O'Grady,Rhonnie Horne,Peter J. O'Brien +9 more
TL;DR: It is concluded that IDCM is associated with a marked impairment of mitochondrial production of ATP, arising from decreased activity of the mitochondrial electron transport system, including myoglobin, which may indicate a deficiency of the mitochondria respiratory chain that predisposes this breed to heart failure.
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High-content analysis for drug delivery and nanoparticle applications
TL;DR: High-content analysis is set to make a major impact in preclinical delivery research by elucidating the intracellular pathways of NPs and the in vitro mechanistic-based toxicology of formulation constituents.