P
Peter Kille
Researcher at Cardiff University
Publications - 217
Citations - 7982
Peter Kille is an academic researcher from Cardiff University. The author has contributed to research in topics: Lumbricus rubellus & Metallothionein. The author has an hindex of 52, co-authored 200 publications receiving 7270 citations. Previous affiliations of Peter Kille include University of Wales & Imperial College London.
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Control genes in quantitative molecular biological techniques: the variability of invariance
TL;DR: All of the widely used control genes are evaluated, dissecting different methodological approaches and issues regarding the experimental context to generate a procedure that will help to discern the best control for novel experiments.
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Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7
Kathryn Mary Taylor,Stephen Edward Hiscox,Robert Ian Nicholson,Christer Hogstrand,Peter Kille +4 more
TL;DR: The present results show that transition element channels in eukaryotes can be activated posttranslationally by phosphorylation, as part of a cell signaling cascade, and suggests that ZIP7 may provide a target for anticancer drug development.
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Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation
TL;DR: The mechanisms of cellular zinc homeostasis are discussed, and an important role is proposed for the zinc transporter solute carrier family 39, member 7 (SLC39A7; commonly referred to as ZIP7), which releases zinc from the endoplasmic reticulum and might be required for tyrosine kinase activation.
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Microevolution and ecotoxicology of metals in invertebrates.
TL;DR: The evidence for the existence of genetically differentiated, metal-resistant, invertebrate populations is surveyed and some of the molecular mechanisms underpinning the adaptations are described, urging that biomarker studies should work toward assimilating and exploiting these biological realities.
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'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
Jacob G. Bundy,Jasmin K Sidhu,Faisal Rana,David J. Spurgeon,Claus Svendsen,Jodie F Wren,Jodie F Wren,Stephen R. Stürzenbaum,A. John Morgan,Peter Kille +9 more
TL;DR: Multiple post-genomic techniques can be combined to provide mechanistic information about the toxic effects of chemical contaminants, even for non-model organisms with few additional mechanistic toxicological data.