P
Peter M. Blumberg
Researcher at National Institutes of Health
Publications - 7
Citations - 2666
Peter M. Blumberg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: TRPV1 & Vanilloids. The author has an hindex of 6, co-authored 7 publications receiving 2600 citations.
Papers
More filters
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.
Journal ArticleDOI
Molecular Determinants of Vanilloid Sensitivity in TRPV1
Narender R. Gavva,Lana Klionsky,Yusheng Qu,Licheng Shi,Rami Tamir,Steven P. Edenson,Tie J. Zhang,Vellarkad N. Viswanadhan,Attila Tóth,Larry V. Pearce,Todd W. Vanderah,Frank Porreca,Peter M. Blumberg,Jack Lile,Yax Sun,Ken Wild,Jean Claude Louis,James J. S. Treanor +17 more
TL;DR: Key residues (Met547 and Thr550) in transmembrane regions 3 and 4 of rat and human TRPV1 that confer vanilloid sensitivity, [3H]RTX binding and competitive antagonist binding to rabbit TRpV1 are identified and it is shown that these residues differentially affect ligand recognition as well as the assays of functional response versus ligand binding.
Journal ArticleDOI
Analysis of the Native Quaternary Structure of Vanilloid Receptor 1
Noemi Kedei,Tamás Szabó,Jack Lile,James J. S. Treanor,Zoltan Olah,Michael J. Iadarola,Peter M. Blumberg +6 more
TL;DR: The results clearly show that VR1 forms multimers in each of the expression systems with a homotetramer as a predominant form, indicating the need for caution in the use of the heterologous expression systems for analysis of VR1 properties.
Journal ArticleDOI
High Affinity Antagonists of the Vanilloid Receptor
Yun Wang,Tamás Szabó,Jacqueline D. Welter,Attila Tóth,Richard Tran,Jiyoun Lee,Sang Uk Kang,Young-Ger Suh,Peter M. Blumberg,Jeewoo Lee +9 more
TL;DR: It is concluded that JYL1421 is a competitive antagonist of rVR1, blocking response to all three of the agonists (capsaicin, heat, and protons) with enhanced potency relative to capsazepine.
Journal ArticleDOI
High-affinity partial agonists of the vanilloid receptor.
Yun Wang,Attila Tóth,Richard Tran,Tamás Szabó,Jacqueline D. Welter,Peter M. Blumberg,Jiyoun Lee,Sang-Uk Kang,Ju-Ok Lim,Jeewoo Lee +9 more
TL;DR: Two compounds are characterized, JYL827 and JYL1511, that function as partial agonists for rat VR1 heterologously expressed in Chinese hamster ovary cells and the strong dependence of such partial agonist on other modulators of rVR1 is predicted to depend strongly on biological context.