Steven P. Edenson

TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.

TL;DR: Key residues (Met547 and Thr550) in transmembrane regions 3 and 4 of rat and human TRPV1 that confer vanilloid sensitivity, [3H]RTX binding and competitive antagonist binding to rabbit TRpV1 are identified and it is shown that these residues differentially affect ligand recognition as well as the assays of functional response versus ligand binding.

TL;DR: It was found that cellular transfectants expressing the fibroblast growth factor receptor 1 variant are mitogenically inactive and ligand binding to the receptor causes neither receptor autophosphorylation nor phospholipase C-gamma transphosphorylated.

TL;DR: These reporter-based assays reflect the mechanisms of action for the therapeutic drugs of interest and are sensitive and quantitative, and able to measure the synergetic effect of PD-1 blockade with a second IC inhibitor receptor blockade or a costimulatory receptor activation.