R
Rami Tamir
Researcher at Amgen
Publications - 23
Citations - 3244
Rami Tamir is an academic researcher from Amgen. The author has contributed to research in topics: TRPV1 & Receptor. The author has an hindex of 17, co-authored 23 publications receiving 3131 citations.
Papers
More filters
Journal ArticleDOI
GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
TL;DR: In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.
Journal ArticleDOI
AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
Narender R. Gavva,Rami Tamir,Yusheng Qu,Lana Klionsky,Tie J. Zhang,David C. Immke,Judy Wang,Dawn Zhu,Todd W. Vanderah,Frank Porreca,Elizabeth M. Doherty,Mark H. Norman,Kenneth D. Wild,Anthony W. Bannon,Jean Claude Louis,James J. S. Treanor +15 more
TL;DR: AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.
Journal ArticleDOI
Molecular Determinants of Vanilloid Sensitivity in TRPV1
Narender R. Gavva,Lana Klionsky,Yusheng Qu,Licheng Shi,Rami Tamir,Steven P. Edenson,Tie J. Zhang,Vellarkad N. Viswanadhan,Attila Tóth,Larry V. Pearce,Todd W. Vanderah,Frank Porreca,Peter M. Blumberg,Jack Lile,Yax Sun,Ken Wild,Jean Claude Louis,James J. S. Treanor +17 more
TL;DR: Key residues (Met547 and Thr550) in transmembrane regions 3 and 4 of rat and human TRPV1 that confer vanilloid sensitivity, [3H]RTX binding and competitive antagonist binding to rabbit TRpV1 are identified and it is shown that these residues differentially affect ligand recognition as well as the assays of functional response versus ligand binding.
Journal ArticleDOI
The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation
Narender R. Gavva,Anthony W. Bannon,Sekhar Surapaneni,David N. Hovland,Sonya G. Lehto,Anu Gore,Todd Juan,Hong Deng,Bora Han,Lana Klionsky,Rongzhen Kuang,April Le,Rami Tamir,Jue Wang,Brad Youngblood,Dawn Zhu,Mark H. Norman,Ella Magal,James J. S. Treanor,Jean-Claude Louis +19 more
TL;DR: It is reported that TRPV1 antagonists representing various chemotypes cause an increase in body temperature (hyperthermia), identifying a potential issue for their clinical development and indicating that tonic TRPv1 activation regulates body temperature.
Journal ArticleDOI
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Narender R. Gavva,Anthony W. Bannon,David N. Hovland,Sonya G. Lehto,Lana Klionsky,Sekhar Surapaneni,David C. Immke,Charles Henley,Leyla Arik,Annette Bak,James Davis,Nadia B. Ernst,Gal Hever,Rongzhen Kuang,Licheng Shi,Rami Tamir,Jue Wang,Weiya Wang,Gary Zajic,Dawn Zhu,Mark H. Norman,Jean-Claude Louis,Ella Magal,James J. S. Treanor +23 more
TL;DR: The in vitro and in vivo characterization of a novel and selective TRPV1 antagonist, AMG 517, and its pharmacology with that of a closely related analog, tert-butyl-2-(6-([2-(acetylamino)-1,3-benzothiazol-4-yl]oxy)pyrimidin- 4-yl)-5-(trifluoromethyl)phenylcarbamate (AMG8163) suggest that