P
Peter R. Durie
Researcher at University of Toronto
Publications - 257
Citations - 18530
Peter R. Durie is an academic researcher from University of Toronto. The author has contributed to research in topics: Cystic fibrosis & Pancreatic disease. The author has an hindex of 70, co-authored 257 publications receiving 17317 citations. Previous affiliations of Peter R. Durie include University Health Network & Ben-Gurion University of the Negev.
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Journal ArticleDOI
Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation
Frank J. Accurso,Steven M. Rowe,John P. Clancy,Michael P. Boyle,Jordan M. Dunitz,Peter R. Durie,Scott D. Sagel,Douglas B. Hornick,Michael W. Konstan,Scott H. Donaldson,Richard B. Moss,Joseph M. Pilewski,Ronald C. Rubenstein,Ahmet Uluer,Moira L. Aitken,Steven D. Freedman,Lynn M. Rose,Nicole Mayer-Hamblett,Qunming Dong,Jiuhong Zha,Anne Stone,Eric R. Olson,Claudia L. Ordoñez,Preston W. Campbell,Melissa A. Ashlock,Bonnie W. Ramsey +25 more
TL;DR: This study showed that VX-770 was associated with within-subject improvements in CFTR and lung function and provides support for further studies of pharmacologic potentiation of CFTR as a means to treat cystic fibrosis.
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The relation between genotype and phenotype in cystic fibrosis--analysis of the most common mutation (delta F508).
Eitan Kerem,Mary Corey,Batsheva Kerem,Johanna M. Rommens,Danuta Markiewicz,Henry Levison,Lap-Chee Tsui,Peter R. Durie +7 more
TL;DR: The variable clinical course in patients with cystic fibrosis can be attributed at least in part to specific genotypes at the locus of the cystic Fibrosis gene.
Journal ArticleDOI
Mutations in SBDS are associated with Shwachman–Diamond syndrome
Graeme R.B. Boocock,Jodi Morrison,Maja Popovic,Nicole Richards,Lynda Ellis,Peter R. Durie,Johanna M. Rommens +6 more
TL;DR: Identification of disease-associated mutations in an uncharacterized gene, SBDS, in the interval of 1.9 cM at 7q11 is reported, suggesting that SDS may be caused by a deficiency in an aspect of RNA metabolism essential for development of the exocrine pancreas, hematopoiesis and chrondrogenesis.
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Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
John P. Clancy,Steven M. Rowe,Frank J. Accurso,Moira L. Aitken,Raouf S. Amin,Melissa A. Ashlock,Manfred Ballmann,Michael P. Boyle,Inez Bronsveld,Preston W. Campbell,Kris De Boeck,Scott H. Donaldson,Henry L. Dorkin,Jordan M. Dunitz,Peter R. Durie,Manu Jain,Anissa Leonard,Karen McCoy,Richard B. Moss,Joseph M. Pilewski,Daniel B. Rosenbluth,Ronald C. Rubenstein,Michael S. Schechter,Martyn Botfield,Claudia L. Ordoñez,George T. Spencer-Green,Laurent Vernillet,Steve Wisseh,Karl Yen,Michael W. Konstan +29 more
TL;DR: In this study, VX-809 had a similar adverse event profile to placebo for 28 days in F508del-CFTR homozygous patients, and demonstrated biological activity with positive impact on CFTR function in the sweat gland.
Journal ArticleDOI
Genetic Modifiers of Lung Disease in Cystic Fibrosis
Mitchell L. Drumm,Michael W. Konstan,Mark D. Schluchter,Allison Handler,Rhonda G. Pace,Fei Zou,Maimoona A. Zariwala,David C. Fargo,Airong Xu,John M. Dunn,Rebecca J. Darrah,Ruslan Dorfman,Andrew J. Sandford,Mary Corey,Julian Zielenski,Peter R. Durie,Katrina A.B. Goddard,James R. Yankaskas,Fred A. Wright,Michael R. Knowles +19 more
TL;DR: Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis.