J
James R. Yankaskas
Researcher at University of North Carolina at Chapel Hill
Publications - 20
Citations - 3858
James R. Yankaskas is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 18, co-authored 20 publications receiving 3605 citations.
Papers
More filters
Journal ArticleDOI
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
D. Worlitzsch,Robert Tarran,Martina Ulrich,Ute E. Schwab,Aynur Cekici,Keith C. Meyer,Peter Birrer,Gabriel Bellon,Jürgen Berger,Tilo Weiss,Konrad Botzenhart,James R. Yankaskas,Scott H. Randell,Richard C. Boucher,Gerd Döring +14 more
TL;DR: In CF patients with established lung disease, Pseudomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens, and in vitro studies revealed that CF-specific increases in epithelial O(2) consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection.
Book ChapterDOI
Well-differentiated human airway epithelial cell cultures.
Journal ArticleDOI
Cystic Fibrosis Adult Care: Consensus Conference Report
TL;DR: Yankaskas, Bruce C. Marshall, Beth Sufian, Richard H. Simon, and David Rodman as discussed by the authors discussed Cystic Fibrosis Adult Care in the American College of Chest Physicians.
Journal ArticleDOI
Genetic Modifiers of Lung Disease in Cystic Fibrosis
Mitchell L. Drumm,Michael W. Konstan,Mark D. Schluchter,Allison Handler,Rhonda G. Pace,Fei Zou,Maimoona A. Zariwala,David C. Fargo,Airong Xu,John M. Dunn,Rebecca J. Darrah,Ruslan Dorfman,Andrew J. Sandford,Mary Corey,Julian Zielenski,Peter R. Durie,Katrina A.B. Goddard,James R. Yankaskas,Fred A. Wright,Michael R. Knowles +19 more
TL;DR: Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis.
Journal ArticleDOI
Diagnostic sweat testing: the Cystic Fibrosis Foundation guidelines.
TL;DR: Specific requirements for sweat testing are outlined, which are applicable to patients of all ages undergoing sweat chloride testing and are focused on diagnostic rather than screening tests.