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Inez Bronsveld
Researcher at Utrecht University
Publications - 32
Citations - 2492
Inez Bronsveld is an academic researcher from Utrecht University. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 14, co-authored 24 publications receiving 2111 citations. Previous affiliations of Inez Bronsveld include University Medical Center Utrecht.
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Journal ArticleDOI
A functional CFTR assay using primary cystic fibrosis intestinal organoids
Johanna F. Dekkers,Caroline L. Wiegerinck,Hugo R. de Jonge,Inez Bronsveld,Hettie M. Janssens,Karin M. de Winter-de Groot,Arianne M. Brandsma,Nienke W M de Jong,Marcel J. C. Bijvelds,Bob J. Scholte,Edward E. S. Nieuwenhuis,Stieneke van den Brink,Hans Clevers,Cornelis K. van der Ent,Sabine Middendorp,Jeffrey M. Beekman +15 more
TL;DR: This relatively simple and robust assay will facilitate diagnosis, functional studies, drug development and personalized medicine approaches in cystic fibrosis.
Journal ArticleDOI
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
John P. Clancy,Steven M. Rowe,Frank J. Accurso,Moira L. Aitken,Raouf S. Amin,Melissa A. Ashlock,Manfred Ballmann,Michael P. Boyle,Inez Bronsveld,Preston W. Campbell,Kris De Boeck,Scott H. Donaldson,Henry L. Dorkin,Jordan M. Dunitz,Peter R. Durie,Manu Jain,Anissa Leonard,Karen McCoy,Richard B. Moss,Joseph M. Pilewski,Daniel B. Rosenbluth,Ronald C. Rubenstein,Michael S. Schechter,Martyn Botfield,Claudia L. Ordoñez,George T. Spencer-Green,Laurent Vernillet,Steve Wisseh,Karl Yen,Michael W. Konstan +29 more
TL;DR: In this study, VX-809 had a similar adverse event profile to placebo for 28 days in F508del-CFTR homozygous patients, and demonstrated biological activity with positive impact on CFTR function in the sweat gland.
Journal ArticleDOI
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
Johanna F. Dekkers,Gitte Berkers,Evelien Kruisselbrink,Annelotte M. Vonk,Hugo R. de Jonge,Hettie M. Janssens,Inez Bronsveld,Eduard A. van de Graaf,Edward E. S. Nieuwenhuis,Roderick H. J. Houwen,Frank P. Vleggaar,Johanna C. Escher,Yolanda B. de Rijke,Christof J. Majoor,Harry G.M. Heijerman,Karin M. de Winter-de Groot,Hans Clevers,Cornelis K. van der Ent,Jeffrey M. Beekman +18 more
TL;DR: In vitro measurements of CFTR function in patient-derived rectal organoids may be useful for identifying subjects who would benefit from CFTR-correcting treatment, independent of their CFTR mutation.
Journal ArticleDOI
Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial
Eitan Kerem,Michael W. Konstan,Kris De Boeck,Frank J. Accurso,Isabelle Sermet-Gaudelus,Michael Wilschanski,J. Stuart Elborn,Paola Melotti,Inez Bronsveld,Isabelle Fajac,Anne Malfroot,Daniel B. Rosenbluth,Patricia A Walker,Susanna A. McColley,Christiane Knoop,Serena Quattrucci,Ernst Rietschel,Pamela L. Zeitlin,Jay A. Barth,Gary Elfring,Ellen Welch,Arthur Branstrom,R. Spiegel,Stuart W. Peltz,Temitayo Ajayi,Steven M. Rowe +25 more
TL;DR: Although ataluren did not improve lung function in the overall population of nonsense-mutation cystic fibrosis patients who received this treatment, it might be beneficial for patients not taking chronic inhaled tobramycin.
Journal ArticleDOI
New clinical diagnostic procedures for cystic fibrosis in Europe
K. De Boeck,Nico Derichs,Isabelle Fajac,H. R. De Jonge,Inez Bronsveld,I. Sermet,François Vermeulen,David N. Sheppard,Harry Cuppens,Martin J. Hug,Paola Melotti,Peter G. Middleton,Michael Wilschanski +12 more
TL;DR: New approaches to evaluate the sweat gland, future of genetic testing and methods on the horizon like CFTR expression in human leucocytes and erythrocytes are discussed briefly.