P
Peter Schjerling
Researcher at University of Copenhagen
Publications - 216
Citations - 16136
Peter Schjerling is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Skeletal muscle & Tendon. The author has an hindex of 60, co-authored 202 publications receiving 14583 citations. Previous affiliations of Peter Schjerling include Rigshospitalet & Copenhagen University Hospital.
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Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
TL;DR: Strenuous exercise induces an increase in the pro‐inflammatory cytokines TNFα and IL‐1β and a dramatic increases in the inflammation responsive cytokine IL‐6, which is balanced by the release of cytokine inhibitors (IL‐1ra, sT NF‐r1 and sTNF‐r2) and the anti‐inflammatoryocyte IL‐10.
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Interleukin-6 stimulates lipolysis and fat oxidation in humans.
Gerrit van Hall,Adam Steensberg,Massimo Sacchetti,Christian P. Fischer,Charlotte Keller,Peter Schjerling,Natalie Hiscock,Kirsten Møller,Bengt Saltin,Mark A. Febbraio,Bente Klarlund Pedersen +10 more
TL;DR: The data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.
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Muscle-derived interleukin-6: possible biological effects.
TL;DR: Muscle‐derived IL‐6 is released into the circulation during exercise in high amounts and is likely to work in a hormone‐like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise‐induced lipolysis.
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Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle
Sebastian B. Jørgensen,Benoit Viollet,Fabrizio Andreelli,Christian Frøsig,Jesper B. Birk,Peter Schjerling,Sophie Vaulont,Erik A. Richter,Jørgen F. P. Wojtaszewski +8 more
TL;DR: The results show that α2-AMPK is the main donor of basal and AICAR-stimulated AMPK activity and is responsible for A ICAR-induced glucose uptake.
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Vitamin D controls T cell antigen receptor signaling and activation of human T cells
Marina Rode von Essen,Martin Kongsbak,Peter Schjerling,Klaus Olgaard,Niels Ødum,Carsten Geisler +5 more
TL;DR: It is shown that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells, however, TCR triggering led to an upregulation of ∼75-fold in PLC -γ1 expression, which correlated with greater TCR responsiveness.