P
Petr Broz
Researcher at University of Lausanne
Publications - 112
Citations - 13355
Petr Broz is an academic researcher from University of Lausanne. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 42, co-authored 87 publications receiving 9389 citations. Previous affiliations of Petr Broz include University of Basel & Stanford University.
Papers
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Journal ArticleDOI
Inflammasomes: mechanism of assembly, regulation and signalling
Petr Broz,Vishva M. Dixit +1 more
TL;DR: This Review discusses the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammaome assembly, signalling and regulation.
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lorenzo Sborgi,Sebastian Rühl,Estefania Mulvihill,Joka Pipercevic,Rosalie Heilig,Henning Stahlberg,Christopher J. Farady,Daniel J. Müller,Petr Broz,Sebastian Hiller +9 more
TL;DR: Overall, these data demonstrate that GSDMD is the direct and final executor of pyroptotic cell death.
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The gasdermins, a protein family executing cell death and inflammation
TL;DR: This Review provides a comprehensive overview of the gasdermin family, the mechanisms that control their activation and their role in inflammatory disorders and cancer.
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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
TL;DR: It is shown that macrophage cell death and cytokine maturation in response to infection with diverse bacterial pathogens can be separated genetically and that two distinct inflammasome complexes mediate these events.
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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
TL;DR: It is shown that the NLRs NLRP3 and NLRC4 both activate caspase-1 in response to Salmonella typhimurium, and this results reveal unexpected redundancy among NLRs in host defense against intracellular pathogens in vivo.