Christopher J. Farady

TL;DR: Overall, these data demonstrate that GSDMD is the direct and final executor of pyroptotic cell death.

TL;DR: It is demonstrated that during extrinsic apoptosis, caspase‐1 and caspasing‐8 cleave GSDMD to promote lytic cell death and that channel‐forming glycoprotein pannexin‐1, but not G SDMD or GSDME promotes NLRP3 inflammasome activation during casp enzyme‐8 or caspases‐9‐dependent apoptosis.

TL;DR: It is demonstrated that conditioning regimen-induced ATP release is a primary driver of MDSC dysfunction through ATP receptor (P2x7R) engagement and NLRP3 inflammasome activation and this findings inform future clinical trials that would use M DSC to decrease alloresponses in inflammatory environments.

TL;DR: In this paper, a crystal structure of the NLRP3 NACHT domain in complex with an inhibitor is presented, showing the inhibitor acts as an intramolecular glue, which locks the protein in an inactive conformation.

TL;DR: The combination of novel cell line engineering tools, next‐generation sequencing screening methods, and the recently published Chinese hamster genome has enabled the development of this novel matriptase KO CHO cell line capable of improving expression yields of intact therapeutic proteins.