P
Petr Protiva
Researcher at Yale University
Publications - 36
Citations - 1448
Petr Protiva is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 26 publications receiving 1328 citations. Previous affiliations of Petr Protiva include Columbia University & University of Connecticut Health Center.
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Journal ArticleDOI
Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1
Leonardo Pignataro,Alexandria N. Miller,Limei Ma,Shonali Midha,Petr Protiva,Daniel G. Herrera,Neil L. Harrison +6 more
TL;DR: It is suggested that alcohol activates phylogenetically conserved pathways that involve intermediates in the heat shock cascade and that sequence elements similar to the ARE may mediate some of the changes in gene expression triggered by alcohol intake, which could be important in a variety of pathophysiological responses to alcohol.
Journal ArticleDOI
Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response.
Petr Protiva,Petr Protiva,Petr Protiva,Michael E. Hopkins,Scott Baggett,Hui Yang,Martin Lipkin,Peter R. Holt,Edward J. Kennelly,Weinstein I. Bernard +9 more
TL;DR: X, GE and GH appear to inhibit the growth of human colon cancer cells, at least in part, by activating the endoplasmic reticulum stress response and inhibiting the mTOR cell survival pathway.
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Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells.
TL;DR: In conclusion, selective Cox-2 inhibitors can induce apoptosis independent ofcox-2 expression, however they may selectively target cells that express Cox-1 by decreasing their Cox- 2 protein expression.
Journal ArticleDOI
Antioxidant and cytotoxic isoprenylated coumarins from Mammea americana.
Hui Yang,Petr Protiva,Roberto R. Gil,Bei Jiang,Scott Baggett,Margaret J. Basile,Kurt A. Reynertson,I. Bernard Weinstein,Edward J. Kennelly +8 more
TL;DR: Antioxidant-guided fractionation of Mammea americana L. seeds resulted in the identification of three new isoprenylated coumarins, mammea B/BA hydroxycyclo F (1,1-diphenyl-2-picrylhydrazyl) and mamMea E/BD (2,3), which induce apoptosis and were used to study the structure-activity relationships for this class of compounds.
Journal ArticleDOI
Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity.
Petr Protiva,Heide S. Cross,Michael E. Hopkins,Enikö Kállay,Giovanna Bises,Eleanor Dreyhaupt,Leonard H. Augenlicht,Martin Lipkin,Martin Lesser,Elayne Livote,Peter R. Holt +10 more
TL;DR: The data suggest that the chemopreventive action of hormone replacement therapy on colon neoplasia results, at least in part, from changes in vitamin D activity.