P
Petra A. Wachholz
Researcher at National Institutes of Health
Publications - 11
Citations - 1684
Petra A. Wachholz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immunoglobulin E & Antibody. The author has an hindex of 9, co-authored 11 publications receiving 1597 citations. Previous affiliations of Petra A. Wachholz include Imperial College London & Syngenta.
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Journal ArticleDOI
Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity
Kayhan T. Nouri-Aria,Petra A. Wachholz,J.N. Francis,Mikila R. Jacobson,Samantha Walker,Louisa K. Wilcock,Steven Q. Staple,R. C. Aalberse,Stephen J. Till,Stephen R. Durham +9 more
TL;DR: Grass pollen immunotherapy may induce allergen-specific, IL-10-dependent “protective” IgG4 responses and both the increases in IgG and the IgG “blocking” activity correlated with the patients’ overall assessment of improvement.
Journal ArticleDOI
Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.
Louisa K. James,Mohamed H. Shamji,Samantha Walker,Duncan R. Wilson,Petra A. Wachholz,J.N. Francis,Mikila R. Jacobson,Ian Kimber,Stephen J. Till,Stephen R. Durham +9 more
TL;DR: Grass pollen immunotherapy induces a subpopulation of allergen-specific IgG antibodies with potent inhibitory activity against IgE that persists after treatment discontinuation and that could account for long-term clinical tolerance.
Journal ArticleDOI
Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy
TL;DR: It is concluded that allergen-specific IgG antibodies induced by immunotherapy can disrupt formation of allergenic-IgE complexes that bind to antigen-presenting cells and facilitate allerGEN presentation.
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Mechanisms of immunotherapy: IgG revisited.
TL;DR: Results suggest that successful specific immunotherapy is associated with an increase in IgG blocking activity that is not solely dependent on the quantity of IgG antibodies.
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The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses.
Mohamed H. Shamji,Louisa K. Wilcock,Petra A. Wachholz,Rebecca J. Dearman,Ian Kimber,Peter Adler Würtzen,Mark Larché,Stephen R. Durham,J.N. Francis +8 more
TL;DR: The IgE-FAB assay is reproducible, robust, sensitive and a specific method suitable as a tool for monitoring inhibitory antibody function from patients receiving allergen immunotherapy.