G
Geertrui Denecker
Researcher at Ghent University
Publications - 57
Citations - 7115
Geertrui Denecker is an academic researcher from Ghent University. The author has contributed to research in topics: Apoptosis & Tumor necrosis factor alpha. The author has an hindex of 35, co-authored 56 publications receiving 6722 citations. Previous affiliations of Geertrui Denecker include Université catholique de Louvain & Maastricht University.
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Journal ArticleDOI
Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
Dominique Vercammen,Rudi Beyaert,Geertrui Denecker,V. Goossens,Geert van Loo,Wim Declercq,J. Grooten,Walter Fiers,Peter Vandenabeele +8 more
TL;DR: Results indicate an involvement of caspases in protection against TNF-induced formation of oxygen radicals and necrosis, and zVAD-fmk–dependent sensitization of TNF cytotoxicity could be completely inhibited by the oxygen radical scavenger butylated hydroxyanisole.
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Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
Dominique Vercammen,Greet Brouckaert,Geertrui Denecker,Marc Van de Craen,Wim Declercq,Walter Fiers,Peter Vandenabeele +6 more
TL;DR: Results demonstrate the existence of two different pathways originating from the Fas receptor, one rapidly leading to apoptosis, and, if this apoptotic pathway is blocked by caspase inhibitors, a second directing the cells to necrosis and involving oxygen radical production.
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Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
Marc A. R. C. Daemen,Cornelis van 't Veer,Geertrui Denecker,Vincent H. Heemskerk,Tim G. A. M. Wolfs,Matthias Clauss,Peter Vandenabeele,Wim A. Buurman +7 more
TL;DR: It is suggested that apoptosis is a crucial event that can initiate reperfusion-induced inflammation and subsequent tissue injury in the kidney, and potentially in other organs.
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Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
Sigrid Cornelis,Yanik Bruynooghe,Geertrui Denecker,Sofie Van Huffel,Sandrine A. Tinton,Rudi Beyaert +5 more
TL;DR: In this article, two PITSLRE protein kinase isoforms, namely p11O(PITSLRE) and p58(PitSLRE), are translated from a single transcript by initiation at alternative in-frame AUG codons.
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Caspase-14 protects against epidermal UVB photodamage and water loss.
Geertrui Denecker,Esther Hoste,Barbara Gilbert,Tino Hochepied,Petra Ovaere,Saskia Lippens,Caroline Van den Broecke,Petra Van Damme,Katharina D'Herde,Jean Pierre Hachem,Gaetan Borgonie,Richard B. Presland,Luc Schoonjans,Claude Libert,Joël Vandekerckhove,Kris Gevaert,Peter Vandenabeele,Wim Declercq +17 more
TL;DR: The skin of caspase-14-deficient mice was highly sensitive to the formation of cyclobutane pyrimidine dimers after UVB irradiation, leading to increased levels of UVB-induced apoptosis, and removal of the stratum corneum indicate that casp enzyme-14 controls the UVB scavenging capacity of the Stratum Corneum.