D
Danny Huylebroeck
Researcher at Erasmus University Medical Center
Publications - 189
Citations - 16217
Danny Huylebroeck is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Cellular differentiation & Transcription factor. The author has an hindex of 66, co-authored 180 publications receiving 15091 citations. Previous affiliations of Danny Huylebroeck include National Institute for Medical Research & Innogenetics.
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Journal ArticleDOI
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion
Joke Comijn,Geert Berx,Petra Vermassen,Kristin Verschueren,Leonardus Van Grunsven,Erik Bruyneel,Marc Mareel,Danny Huylebroeck,Frans van Roy +8 more
TL;DR: It is reported that expression of wild-type but not of mutated SIP1 downregulates mammalian E-cadherin transcription via binding to both conserved E2 boxes of the minimal E- cadheringin promoter.
Journal ArticleDOI
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
TL;DR: XTC-MIF is shown to be the homologue of mammalian activin A, a protein produced by Xenopus XTC cells that modulate the release of follicle-stimulating hormone from cultured anterior pituitary cells and cause the differentiation of two erythroleukaemia cell lines.
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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
An Herreman,Dieter H. Hartmann,Wim Annaert,Paul Saftig,Katleen Craessaerts,Lutgarde Serneels,Lieve Umans,Vincent Schrijvers,Frédéric Checler,Hugo Vanderstichele,Veerle Baekelandt,Ralf Dressel,Philippe Cupers,Danny Huylebroeck,An Zwijsen,Fred Van Leuven,Bart De Strooper +16 more
TL;DR: It is demonstrated in vivo that PS1 and PS2 have partially overlapping functions and thatPS1 is essential andPS2 is redundant for normal Notch signaling during mammalian embryological development.
Journal ArticleDOI
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Hidetoshi Yamashita,P. ten Dijke,Danny Huylebroeck,T. K. Sampath,M Andries,James C. Smith,C H Heldin,Kohei Miyazono +7 more
TL;DR: Results indicate that ActR-II can act as a functional type II receptor for OP-1, as well as for activins, and may have broader effects in vivo than hitherto recognized.
Journal ArticleDOI
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
Kristin Verschueren,Jacques E. Remacle,Clara Collart,Clara Collart,Harry Kraft,Harry Kraft,Betty S. Baker,Przemko Tylzanowski,Luc Nelles,Gunther Wuytens,Gunther Wuytens,Ming Tsan Su,Rolf Bodmer,James C. Smith,Danny Huylebroeck,Danny Huylebroeck +15 more
TL;DR: A novel Smad-interacting protein, SIP1, which was identified using the yeast two-hybrid system and is likely to be a transcriptional repressor, which may be involved in the regulation of at least one immediate response gene for activin-dependent signal transduction pathways.