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Philine Guckelberger
Researcher at Max Planck Society
Publications - 3
Citations - 261
Philine Guckelberger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Enhancer & Chromatin. The author has an hindex of 2, co-authored 2 publications receiving 172 citations.
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Journal ArticleDOI
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis
Bjørt K Kragesteen,Malte Spielmann,Malte Spielmann,Christina Paliou,Christina Paliou,Verena Heinrich,Robert Schöpflin,Robert Schöpflin,Andrea Esposito,Carlo Annunziatella,Simona Bianco,Andrea M. Chiariello,Ivana Jerković,Ivana Jerković,Izabela Harabula,Philine Guckelberger,Michael Pechstein,Lars Wittler,Wing Lee Chan,Martin Franke,Martin Franke,Darío G. Lupiáñez,Katerina Kraft,Katerina Kraft,Bernd Timmermann,Martin Vingron,Axel Visel,Axel Visel,Axel Visel,Mario Nicodemi,Stefan Mundlos,Stefan Mundlos,Guillaume Andrey,Guillaume Andrey +33 more
TL;DR: Tissue-specific three-dimensional chromatin conformation can contribute to enhancer activity and specificity in vivo and its disturbance can result in gene misexpression and disease.
Journal ArticleDOI
Preformed chromatin topology assists transcriptional robustness of Shh during limb development.
Christina Paliou,Christina Paliou,Philine Guckelberger,Robert Schöpflin,Robert Schöpflin,Verena Heinrich,Andrea Esposito,Andrea M. Chiariello,Simona Bianco,Carlo Annunziatella,Johannes Helmuth,Stefan A. Haas,Ivana Jerković,Norbert Brieske,Lars Wittler,Bernd Timmermann,Mario Nicodemi,Martin Vingron,Stefan Mundlos,Stefan Mundlos,Guillaume Andrey,Guillaume Andrey +21 more
TL;DR: The results indicate that the preformed chromatin structure of the Shh locus is sustained by multiple components and acts to reinforce enhancer–promoter communication for robust transcription.
Posted ContentDOI
Mapping the convergence of genes for coronary artery disease onto endothelial cell programs
Gavin R. Schnitzler,Helen Y. Kang,Vivian S. Lee-Kim,X. Rosa Ma,Tony Zeng,Ramcharan Singh Angom,Shih Chin Fang,Shamsudheen Karuthedath Vellarikkal,Ronghao Zhou,Katherine Guo,Oscar Sias-Garcia,Alexander Bloemendal,Glen Munson,Philine Guckelberger,Drew T. Bergman,Nathan Cheng,Brian Cleary,Krishna G. Aragam,Debabrata Mukhopadhyay,Eric S. Lander,Hilary K. Finucane,Rajat M. Gupta,Jesse M. Engreitz +22 more
TL;DR: In this paper , the role of endothelial cells in the genetics of coronary artery disease (CAD) was investigated by using the Activity-by-Contact model to link disease variants to genes to programs.