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Andrea Esposito
Researcher at University of Naples Federico II
Publications - 58
Citations - 1069
Andrea Esposito is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Chromatin & Medicine. The author has an hindex of 13, co-authored 42 publications receiving 672 citations. Previous affiliations of Andrea Esposito include Max Delbrück Center for Molecular Medicine & Istituto Nazionale di Fisica Nucleare.
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Journal ArticleDOI
Polymer physics of chromosome large-scale 3D organisation.
TL;DR: It is shown that genome-wide chromatin architecture data, as mapped by Hi-C methods across mammalian cell types and chromosomes, are well described by classical scaling concepts of polymer physics, from the sub-Mb to chromosomal scales.
Journal ArticleDOI
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis
Bjørt K Kragesteen,Malte Spielmann,Malte Spielmann,Christina Paliou,Christina Paliou,Verena Heinrich,Robert Schöpflin,Robert Schöpflin,Andrea Esposito,Carlo Annunziatella,Simona Bianco,Andrea M. Chiariello,Ivana Jerković,Ivana Jerković,Izabela Harabula,Philine Guckelberger,Michael Pechstein,Lars Wittler,Wing Lee Chan,Martin Franke,Martin Franke,Darío G. Lupiáñez,Katerina Kraft,Katerina Kraft,Bernd Timmermann,Martin Vingron,Axel Visel,Axel Visel,Axel Visel,Mario Nicodemi,Stefan Mundlos,Stefan Mundlos,Guillaume Andrey,Guillaume Andrey +33 more
TL;DR: Tissue-specific three-dimensional chromatin conformation can contribute to enhancer activity and specificity in vivo and its disturbance can result in gene misexpression and disease.
Journal ArticleDOI
Preformed chromatin topology assists transcriptional robustness of Shh during limb development.
Christina Paliou,Christina Paliou,Philine Guckelberger,Robert Schöpflin,Robert Schöpflin,Verena Heinrich,Andrea Esposito,Andrea M. Chiariello,Simona Bianco,Carlo Annunziatella,Johannes Helmuth,Stefan A. Haas,Ivana Jerković,Norbert Brieske,Lars Wittler,Bernd Timmermann,Mario Nicodemi,Martin Vingron,Stefan Mundlos,Stefan Mundlos,Guillaume Andrey,Guillaume Andrey +21 more
TL;DR: The results indicate that the preformed chromatin structure of the Shh locus is sustained by multiple components and acts to reinforce enhancer–promoter communication for robust transcription.
Journal ArticleDOI
Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
Mattia Conte,Luca Fiorillo,Simona Bianco,Andrea M. Chiariello,Andrea Esposito,Mario Nicodemi +5 more
TL;DR: Polymer modeling is used to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin depleted cells, providing evidence that the architecture of the studied loci is controlled by a thermodynamics mechanism of polymer phase separation whereby chromatin self-assembles in segregated globules.
Journal ArticleDOI
Cluster of cardiometabolic risk factors in children with GH deficiency: a prospective, case-control study.
Donatella Capalbo,Giuseppina Mattace Raso,Andrea Esposito,Raffaella Di Mase,Flavia Barbieri,Rosaria Meli,Dario Bruzzese,Mariacarolina Salerno +7 more
TL;DR: The aim of this study was to evaluate the effects of GHD and GH therapy on early cardiometabolic risk factors in a large cohort of children.