P
Philip Hallenborg
Researcher at University of Southern Denmark
Publications - 28
Citations - 1752
Philip Hallenborg is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Adipogenesis & Adipose tissue. The author has an hindex of 17, co-authored 25 publications receiving 1464 citations. Previous affiliations of Philip Hallenborg include University of Copenhagen.
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Journal ArticleDOI
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Vyacheslav Akimov,Inigo Barrio-Hernandez,Sten V F Hansen,Philip Hallenborg,Anna-Kathrine Pedersen,Dorte B. Bekker-Jensen,Michele Puglia,Stine Duelund Kaas Christensen,Jens T. Vanselow,M. Nielsen,Irina Kratchmarova,Christian D. Kelstrup,Jesper V. Olsen,Blagoy Blagoev +13 more
TL;DR: Using UbiSite, an antibody-based approach that specifically detects protein lysine and N-terminal ubiquitination, Blagoev and colleagues uncover lack of correlation between changes in protein Ubiquitination and abundance upon proteasome inhibition.
Journal ArticleDOI
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.
Jacob B. Hansen,Claus Jørgensen,Rasmus Koefoed Petersen,Philip Hallenborg,Rita De Matteis,Hans A. Bøye,Natasa Petrovic,Sven Enerbäck,Jan Nedergaard,Saverio Cinti,Hein te Riele,Karsten Kristiansen +11 more
TL;DR: It is proposed that the retinoblastoma protein pRB acts as a molecular switch determining white vs. brown adipogenesis, suggesting a previously uncharacterized function of this key cell cycle regulator in adipocyte lineage commitment and differentiation.
Journal ArticleDOI
UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity
Lise Madsen,Lise Madsen,Lone Møller Pedersen,Haldis H. Lillefosse,Haldis H. Lillefosse,Even Fjære,Even Fjære,Ingeborg Brønstad,Qin Hao,Rasmus Koefoed Petersen,Philip Hallenborg,Tao Ma,Rita De Matteis,Pedro Araujo,Josep Mercader,M. Luisa Bonet,Jacob B. Hansen,Barbara Cannon,Jan Nedergaard,Jun Wang,Saverio Cinti,Peter J. Voshol,Stein Ove Døskeland,Karsten Kristiansen +23 more
TL;DR: The results indicate that cyclooxygenase-dependent induction of UCP1 expression in white adipose tissues is important for diet-induced thermogenesis providing support for a surprising role of COX activity in the control of energy balance and obesity development.
Journal ArticleDOI
Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes
Rasmus Koefoed Petersen,Lise Madsen,Lise Madsen,Lise Madsen,Lone Møller Pedersen,Philip Hallenborg,Hanne R. Hagland,Kristin Viste,Stein Ove Døskeland,Karsten Kristiansen +9 more
TL;DR: This work shows that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for cAMP-dependent stimulation of adipocyte differentiation.
Journal ArticleDOI
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process
Lise Madsen,Rasmus Koefoed Petersen,Morten B Sørensen,Claus Jørgensen,Philip Hallenborg,Lone Pridal,Jan Fleckner,Ez-Zoubir Amri,Peter Krieg,Gerhard Fürstenberger,Rolf K. Berge,Karsten Kristiansen +11 more
TL;DR: It is demonstrated that adipogenic conversion of 3T3-L1 cells requires PPARgamma ligands only during the first 4 days of the differentiation process, and suggested that endogenous PPARGamma ligand(s) promoting adipocyte differentiation are generated via a baicalein-sensitive pathway involving the novel eLOX-3.