P
Philip L. Fuchs
Researcher at Purdue University
Publications - 319
Citations - 6425
Philip L. Fuchs is an academic researcher from Purdue University. The author has contributed to research in topics: Sulfone & Cephalostatin. The author has an hindex of 40, co-authored 319 publications receiving 6220 citations. Previous affiliations of Philip L. Fuchs include University of East Anglia.
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Polyphosphoric acid trimethylsilyl ester promoted intramolecular acylation of an olefin by a carboxylic acid: convenient construction of C-18-functionalized delta14-hecogenin acetate.
Wei Li,Philip L. Fuchs +1 more
TL;DR: Polyphosphoric acid trimethylsilyl ester (PPSE)-promoted intramolecular Friedel-Crafts reactions on a nonaromatic carboxylic acid system have been investigated and led to the synthesis of C-18 functionalized steroidal compounds 5 and 9a-d with strict retention of the spiroketals.
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Designer discodermolide segments via ozonolysis of vinyl phosphonates.
TL;DR: To apply the collection of enantiopure 7-ring vinyl sulfones to probe the anticancer SAR of a series of computer-designed (+)-discodermolide analogs, the ozonolytic reactivity of transposed cyclic vinyl phosphonates was explored.
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Noteworthy observations accompanying synthesis of the apoptolidin disaccharide
TL;DR: A stereoselective synthesis of the apoptolidin disaccharide is reported, which features a new transformation utilizing a highly selective tetramethylalkoxyalanate[v]-directed syn-methylation of a vinylogous ester.
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New Synthetic Methods Exploiting Vinyl Sulfones Discovered During the Synthesis of a Natural Product
TL;DR: In this paper, the alkylation and conjugate-addition chemistry of γ-methoxy allylsulfonyl anions was used for the synthesis of homoharringtonine.
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Intramolecular acylation of an α-sulfonyl anion generated via halogen-metal exchange of an α-halosulfone bearing an unsymmetrical anhydride
TL;DR: The α-Halosulfones are useful for the in situ preparation of α-sulfonyl anions in the presence of acylating agents bearing enolizable protons.