P
Philip L. Fuchs
Researcher at Purdue University
Publications - 319
Citations - 6425
Philip L. Fuchs is an academic researcher from Purdue University. The author has contributed to research in topics: Sulfone & Cephalostatin. The author has an hindex of 40, co-authored 319 publications receiving 6220 citations. Previous affiliations of Philip L. Fuchs include University of East Anglia.
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Journal ArticleDOI
Synthesis of a 17-Deoxy, C-14,15-Dihydro Derivative of the North Spiroketal Moiety of the Cephalostatins. Conversion to a (+)-Trisdecacyclic C2 Symmetrical Pyrazine
Jae Uk Jeong,Philip L. Fuchs +1 more
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An efficient synthesis of the C-23 deoxy, 17 alpha-hydroxy South 1 hemisphere and its cephalostatin 1 analog.
Wei Li,Philip L. Fuchs +1 more
TL;DR: This study led to efficient syntheses of 3 and the subsequent 23'-deoxy,17'alpha-hydroxy cephalostatin 1 analog (4), which are in the low nanomolar range for a 10-cell-line minipanel.
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Cytochalasin support studies. 10. Nucleophilic and electrophilic mercaptanylations via 2-(trimethylsilyl)ethanethiol-derived reagents
TL;DR: Le trimethylsilyl-2 ethanethiol reagit avec des acides carboxyliques, des halogenures d'alkyles, des epoxydes and des enones, pour donner des acyl- ou alkyl trimethyl silyl 2 ethyl sulfures.
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A versatile and expedient synthesis of .alpha.,.beta.-unsaturated ketones. Utilization of the .beta.-epoxy sulfone functional group as the enone progenitor
P. C. Conrad,Philip L. Fuchs +1 more
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Synthesis and pharmacological evaluation of nonacyclic and trisdecacyclic pyrazines related to cephalostatin
TL;DR: In this article, an unusual azide-mediated formation of an unsymmetrical heterobenzyl azide was observed in vitro testing of the symmetrical pyrazines revealed cytotoxicity of about 10−5 M; the azidopyrazine was about 100-fold more cytotoxic.