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Philipp Stawowy
Researcher at Charité
Publications - 92
Citations - 2356
Philipp Stawowy is an academic researcher from Charité. The author has contributed to research in topics: Furin & Integrin. The author has an hindex of 26, co-authored 88 publications receiving 2026 citations. Previous affiliations of Philipp Stawowy include B. Braun Melsungen.
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Journal ArticleDOI
Leptin Induces Endothelial Cell Migration Through Akt, Which Is Inhibited by PPARγ-Ligands
Stephan Goetze,Anne Bungenstock,Cornelia Czupalla,Friedrich Eilers,Philipp Stawowy,Ulrich Kintscher,Chantel Spencer-Hänsch,Kristof Graf,Bernd Nürnberg,Ronald E. Law,Eckart Fleck,Michael Gräfe +11 more
TL;DR: It is demonstrated that leptin induces EC migration, and the first evidence is provided that activation of Akt and ERK 1/2 are crucial events in leptin-mediated signal transduction leading to EC migration.
Journal ArticleDOI
PPAR activators inhibit endothelial cell migration by targeting Akt
Stephan Goetze,Friedrich Eilers,Anne Bungenstock,Ulrich Kintscher,Philipp Stawowy,Florian Blaschke,Kristof Graf,Ronald E. Law,Eckart Fleck,Michael Gräfe +9 more
TL;DR: First evidence for the antimigratory effects of PPAR-activators in EC is provided, indicating that they inhibit migration either downstream of ERK MAPK or independent from this pathway.
Journal ArticleDOI
Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial
Felix Mahfoud,Daniel Urban,Desiree Teller,Dominik Linz,Philipp Stawowy,Jan Hendrik Hassel,Peter Fries,Stephan Dreysse,Ernst Wellnhofer,Günther Schneider,Arno Buecker,Christopher Schneeweis,Adelina Doltra,Markus P. Schlaich,Murray D. Esler,Eckart Fleck,Michael Böhm,Sebastian Kelle +17 more
TL;DR: Catheter-based RDN significantly reduced BP and LVMI and improved EF and circumferential strain in patients with resistant hypertension, occurring partly BP independently.
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Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone's Antifibrotic Activity.
Jana Grune,Niklas Beyhoff,Elia Smeir,Remigiusz Chudek,Annelie Blumrich,Zsofia Ban,Sarah Brix,Iris R. Betz,Michael Schupp,Anna Foryst-Ludwig,Robert Klopfleisch,Philipp Stawowy,René Houtman,Peter Kolkhof,Ulrich Kintscher +14 more
TL;DR: It is demonstrated that the nonsteroidal MRA finerenone potently prevents cardiac fibrosis and improves strain parameters in mice, and selective MR cofactor modulation provides a molecular basis for distinct (pre)-clinical actions of nonsteroid and steroidal MRAs.
Journal ArticleDOI
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Philipp Stawowy,Heike Meyborg,Dietger Stibenz,Núbia Borges Pereira Stawowy,Mattias Roser,Usan Thanabalasingam,John P. Veinot,Michel Chrétien,Nabil G. Seidah,Eckart Fleck,Kristof Graf +10 more
TL;DR: Furin-like PCs (furin and PC5) play a central role in a MT-MMP–MMP-2 proteolytic cascade, involving provision of macrophage MT1-M MP for the activation of pro-Mmp-2 synthesized by other cells.