J
Jean-Marc Treluyer
Researcher at University of Paris
Publications - 53
Citations - 3108
Jean-Marc Treluyer is an academic researcher from University of Paris. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 13, co-authored 53 publications receiving 1957 citations. Previous affiliations of Jean-Marc Treluyer include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Nikaïa Smith,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Rémy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali Anne Szwebel,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Solen Kernéis,Benjamin Terrier +32 more
TL;DR: The results of this trio of studies suggest that the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
Posted ContentDOI
Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Remy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali-Anne Szwebel,Nikaïa Smith,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Benjamin Terrier +29 more
TL;DR: It is proposed that type-I IFN deficiency in the blood is a hallmark of severe Covid-19 and could identify and define a high-risk population and raise concern for utilization of drugs that interfere with the IFN pathway.
Journal ArticleDOI
Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
C. Cazeneuve,Gérard Pons,E. Rey,Jean-Marc Treluyer,T. Cresteil,G Thiroux,Philippe d'Athis,Georges Olive +7 more
TL;DR: The delay in the maturation of N-1 compared with N-3 and N-7-demethylation is in agreement with previous in vivo data, and the difference in maturational profiles of each metabolic pathway suggests that the reactions depend on different isoenzymes.
Journal ArticleDOI
Relationship between cytochrome 3A activity, inflammatory status and the risk of docetaxel-induced febrile neutropenia: a prospective study
Jérôme Alexandre,Jérôme Alexandre,E. Rey,Véronique Girre,Sophie Grabar,Agnès Tran,V. Montheil,F. Rabillon,Véronique Diéras,Vincent Jullien,P. Herait,Gérard Pons,Jean-Marc Treluyer,François Goldwasser +13 more
TL;DR: Inflammatory status and lymphocyte count should be included in the evaluation of the benefice/risk ratio before the initiation of DCX, because of the risk of febrile neutropenia induced by docetaxel.
Journal ArticleDOI
Evidence of impaired cisapride metabolism in neonates.
TL;DR: The low content of CYP3A4 in the human neonatal liver appears to be responsible for its inability to oxidize cisapride and could explain its accumulation in plasma leading to the cases of QTc prolongation reported in this paediatric population.