P
Philippe Nirdé
Researcher at University of Montpellier
Publications - 12
Citations - 564
Philippe Nirdé is an academic researcher from University of Montpellier. The author has contributed to research in topics: Estrogen receptor alpha & Tumor progression. The author has an hindex of 10, co-authored 12 publications receiving 527 citations. Previous affiliations of Philippe Nirdé include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal Article
Differential Expression of Estrogen Receptor-α and -β Messenger RNAs as a Potential Marker of Ovarian Carcinogenesis
Pascal Pujol,Jean-Marc Rey,Philippe Nirdé,Pascal Roger,Marguerite Gastaldi,François Laffargue,Henri Rochefort,Thierry Maudelonde +7 more
TL;DR: An increase in the ER-α:ER-β mRNA ratio in ovarian carcinomas as compared with normal ovaries and cysts is found, suggesting that overexpression of ER- α relative to ER- β mRNA may be a marker of ovarian carcinogenesis.
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Mannose 6-phosphate receptor targeting and its applications in human diseases.
TL;DR: The synthesis and potential use of high affinity M6P analogues able to target this receptor are highlighted and their potential applications in preventing clinical disorders, which are associated with the activities of other M 6P-proteins involved in wound healing, cell growth or viral infection, are discussed.
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PTPL1/PTPN13 Regulates Breast Cancer Cell Aggressiveness through Direct Inactivation of Src Kinase
Murielle Glondu-Lassis,Mathilde Dromard,Magali Lacroix-Triki,Philippe Nirdé,Carole Puech,Dora Knani,Dany Chalbos,Gilles Freiss +7 more
TL;DR: PTPL1 is identified as the first phosphatase able to inhibit Src through direct dephosphorylation in intact cells, and a new mechanism by which PTPL1 inhibits breast tumor aggressiveness is described.
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Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Philippe Nirdé,Danielle Derocq,Marie Maynadier,Monique Chambon,Ilaria Basile,Magali Gary-Bobo,Marcel Garcia +6 more
TL;DR: A new role of this secreted hsc70 chaperone in cell proliferation that might account for the higher tumor growth of cancer cells overexpressing cath D is suggested.
Journal Article
Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes.
TL;DR: In both, the resistant epimastigote and the resistant amastigotes, growth curves exhibited a lower growth rate than the sensitive counterparts without affecting the viability of the parasites, which could be significant in basic research.