Philippe Terrier

TL;DR: This panel allowed us to characterise paediatric osteosarcomas and the alteration of the 7q31 locus at diagnosis was significantly correlated with a worse prognosis and a new frequently altered locus, 5q21, was described.

TL;DR: PTEN genomic level and protein expression in this large series of sarcomas with complex genomics, as well as activation of downstream pathways, could suggest a link between RICTOR overexpression and leiomyosarcomas oncogenesis.

TL;DR: In leiomyosarcomas compared with other specific tumor types such as undifferentiated pleomorphic sarcoma and myxofibrosarcoma, the accuracy for transgelin varied from 80 to 87% whereas it was lower for all other markers (between 51 and 80%).

TL;DR: The development of peripheral thickening or enhancing nodules within cystic-like metastatic lesions, even without any change in size, represented progressive GIST under Imatinib, growing in a short time and should alert the clinician for the possible need for a change in therapy.

TL;DR: EGFR expression, detected in 86% of MPNSTs, was more frequent in NF1 specimens and closely associated with high-grade and p53-positive areas, which might mean EGFR might become a new target for MPN STs treatment, especially inNF1-associated MPnSTs.