P
Phillip M. Nista
Researcher at Indiana University
Publications - 3
Citations - 1086
Phillip M. Nista is an academic researcher from Indiana University. The author has contributed to research in topics: Genetic variation & Shotgun sequencing. The author has an hindex of 3, co-authored 3 publications receiving 1024 citations.
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Journal ArticleDOI
Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans
David J. Begun,Alisha K. Holloway,Kristian Stevens,LaDeana W. Hillier,Yu Ping Poh,Matthew W. Hahn,Phillip M. Nista,Corbin D. Jones,Andrew D. Kern,Andrew D. Kern,Colin N. Dewey,Lior Pachter,Eugene W. Myers,Charles H. Langley +13 more
TL;DR: A population genetic analysis of Drosophila simulans is presented based on whole-genome shotgun sequencing of multiple inbred lines and comparison of the resulting data to genome assemblies of the closely related species, D. melanogaster and D. yakuba, to suggest several new hypotheses regarding the genetic and biological mechanisms controlling polymorphism and divergence across the Drosophile genome.
Journal ArticleDOI
Genomic Variation in Natural Populations of Drosophila melanogaster
Charles H. Langley,Kristian Stevens,Charis Cardeno,Yuh Chwen G. Lee,Daniel R. Schrider,John E. Pool,Sasha A. Langley,Charlyn Suarez,Russell Corbett-Detig,Bryan Kolaczkowski,Shu Fang,Phillip M. Nista,Alisha K. Holloway,Andrew D. Kern,Colin N. Dewey,Yun S. Song,Matthew W. Hahn,David J. Begun +17 more
TL;DR: This report of independent genome sequences of two natural populations of Drosophila melanogaster provides unique insight into forces shaping genomic polymorphism and divergence, suggesting many targets of directional selection are shared between these species.
Proceedings ArticleDOI
Trinity RNA-Seq assembler performance optimization
TL;DR: A performance study of Trinity is conducted, a series of improvements to Trinity are described, quantify the execution improvements achieved, and the new version of the software is document.