Bryan Kolaczkowski

TL;DR: It is shown that maximum likelihood and BMCMC can become strongly biased and statistically inconsistent when the rates at which sequence sites evolve change non-identically over time.

TL;DR: This report of independent genome sequences of two natural populations of Drosophila melanogaster provides unique insight into forces shaping genomic polymorphism and divergence, suggesting many targets of directional selection are shared between these species.

TL;DR: The early development of the gut microbiomes of 76 children at high genetic risk for T1D was determined using high-throughput 16S rRNA gene sequencing, and one highly abundant group, composed of two closely related species, B. dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion.

TL;DR: Next-generation genome sequencing is used to reexamine the well-studied Australian D. melanogaster cline and reveals evidence for spatially varying selection on a number of key biological processes, suggesting fundamental biological differences between flies from these two geographic regions.

TL;DR: It is shown that incorporating phylogenetic uncertainty by integrating over topologies very rarely changes the inferred ancestral state and does not improve the accuracy of the reconstructed ancestral sequence, suggesting that ML can produce accurate ASRs, even in the face of phylogenetic Uncertainty.