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Phillip P. Toskes
Researcher at University of Florida
Publications - 103
Citations - 5330
Phillip P. Toskes is an academic researcher from University of Florida. The author has contributed to research in topics: Pancreatitis & Breath test. The author has an hindex of 37, co-authored 103 publications receiving 5130 citations. Previous affiliations of Phillip P. Toskes include United States Department of Veterans Affairs & Medical University of South Carolina.
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Journal ArticleDOI
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.
David C. Whitcomb,Michael C. Gorry,Preston Ra,William Furey,Michael Sossenheimer,Charles D. Ulrich,Stephen P. Martin,Lawrence K. Gates,Stephen T. Amann,Phillip P. Toskes,Roger A. Liddle,Kevin McGrath,Generoso Uomo,James Christopher Post,James Christopher Post,Garth D. Ehrlich +15 more
TL;DR: X-ray crystal structure analysis, molecular modelling, and protein digest data indicate that the Arg 117 residue is a trypsin-sensitive site, and that loss of this cleavage site would permit autodigestion resulting in pancreatitis.
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Small Intestine Bacterial Overgrowth
TL;DR: The purpose of this review will be to point out the clinical ramifications of the recent information, and suggest several areas where future investigation might prove fruitful in furthering the understanding of the pathophysiology and management of small intestine bacterial overgrowth.
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American Pancreatic Association practice guidelines in chronic pancreatitis evidence-based report on diagnostic guidelines
Darwin L. Conwell,Linda S. Lee,Dhiraj Yadav,Daniel S. Longnecker,Frank H. Miller,Koenraad J. Mortele,Michael J. Levy,Richard S. Kwon,John G. Lieb,Tyler Stevens,Phillip P. Toskes,Timothy B. Gardner,Andres Gelrud,Bechien U. Wu,Chris E. Forsmark,Santhi Swaroop Vege +15 more
TL;DR: A diagnostic (STEP-wise; survey, tomography, endoscopy, and pancreas function testing) algorithm is proposed that proceeds from a noninvasive to a more invasive approach and a nomenclature is suggested to further characterize patients with established chronic pancreatitis based on TIGAR-O for uniformity across future multicenter research collaborations.
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Protease-specific suppression of pancreatic exocrine secretion
TL;DR: It is demonstrated that pancreatic extract decreases abdominal pain and that intraduodenal perfusion with proteases but not with amylase or lipase suppresses pancreatic exocrine secretion in patients with chronic pancreatitis.
Journal ArticleDOI
Vitamin B 12 malabsorption in chronic pancreatic insufficiency.
TL;DR: Some patients with pancreatic insufficiency show malabsorption of vitamin B12, and the pancreas may have a role in the absorption of this vitamin.