Pierluigi Nicotera

TL;DR: Pulsed ATP/depletion/repletion experiments showed that ATP generation either by glycolysis or by mitochondria was required for the active execution of the final phase of apoptosis, which involves nuclear condensation and DNA degradation.

TL;DR: One general signalling mechanism used to transfer the information delivered by agonists into appropriate intracellular compartments involves the rapid redistribution of ionised calcium throughout the cell, which results in transient elevations of the cytosolic free Ca2+ concentration.

TL;DR: It is shown that intracellular energy levels and mitochondrial function are rapidly compromised in necrosis, but not in apoptosis of neuronal cells, and that pre-empting human T cells of ATP switches the type of demise caused by two classic apoptotic triggers from apoptosis to necrosis.

TL;DR: Increasing evidence suggests that apoptosis and necrosis seem to represent only different shapes of cell demise, resulting from a more or less complete execution of the internal death program.

TL;DR: An increased rate of cell death in the adult nervous system underlies neurodegenerative disease and specific death mechanisms, based on specific neuronal characteristics such as excitability and the presence of specific channels or enzymes, have been unraveled in the brain.