S
Simone Kühnle
Researcher at University of Konstanz
Publications - 16
Citations - 3228
Simone Kühnle is an academic researcher from University of Konstanz. The author has contributed to research in topics: Apoptosis & Ubiquitin ligase. The author has an hindex of 15, co-authored 16 publications receiving 3115 citations. Previous affiliations of Simone Kühnle include Harvard University.
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Journal ArticleDOI
Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
TL;DR: Pulsed ATP/depletion/repletion experiments showed that ATP generation either by glycolysis or by mitochondria was required for the active execution of the final phase of apoptosis, which involves nuclear condensation and DNA degradation.
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Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis.
Marcel Leist,Barbara Single,Heike Naumann,Eugenio Fava,Bernadett Simon,Simone Kühnle,Pierluigi Nicotera +6 more
TL;DR: It is suggested that NO can decide the shape of cell death by lowering intracellular ATP below the level required to allow the coordinated execution of apoptosis.
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Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide.
Marcel Leist,Christiane Volbracht,Simone Kühnle,Eugenio Fava,Elisa Ferrando-May,Pierluigi Nicotera +5 more
TL;DR: In this article, the authors investigated whether triggering of caspase activity and/or activation of poly-(ADP-ribose) polymerase (PARP) played a role in cerebellar granule cell (CGC) apoptosis elicited by peroxynitrite (ONOO−) or NO donors.
Journal Article
Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide
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NSD3–NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism
Christopher A. French,Shaila Rahman,Erica M. Walsh,Simone Kühnle,Adlai R. Grayson,Madeleine E. Lemieux,Noam Grunfeld,Brian P. Rubin,Cristina R. Antonescu,Songlin Zhang,Rajkumar Venkatramani,Paola Dal Cin,Peter M. Howley +12 more
TL;DR: It is found that NSD3-NUT is both necessary and sufficient for the blockade of differentiation and maintenance of proliferation in NMC cells, and the involvement of theNSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target.