Piero O. Bonetti

TL;DR: Given its reversibility and granted the availability of a diagnostic tool to identify patients at risk and to control the efficacy of therapy in clinical practice, endothelial dysfunction may be an attractive primary target in the effort to optimize individualized therapeutic strategies to reduce cardiovascular morbidity and mortality.

TL;DR: Digital hyperemic response, as measured by RH-PAT, is attenuated in patients with coronary microvascular endothelial dysfunction, suggesting a role for RH- PAT as a noninvasive test to identify patients with this disorder.

TL;DR: The striking benefit achieved with statin treatment in patients with a wide range of cholesterol levels, which cannot be attributed to their cholesterol lowering effect alone, has raised the question about the possible presence of additional effects of statins beyond their impact on serum cholesterol levels.

TL;DR: Enhanced external counterpulsation enhances peripheral endothelial function with beneficial effects persisting at one-month follow-up in patients with a positive clinical response, suggesting that improvement in endothelialfunction may contribute to the clinical benefit of EECP in patientsWith symptomatic CAD.

TL;DR: Presence of CED in patients without obstructive CAD is independently associated with an increased risk of cerebrovascular events, and detection of this early stage of atherosclerosis may provide important information to identify patients who benefit from aggressive preventive strategies.