Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
Piero O. Bonetti,Geralyn M. Pumper,Stuart T. Higano,David R. Holmes,Jeffrey T. Kuvin,Amir Lerman +5 more
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TLDR
Digital hyperemic response, as measured by RH-PAT, is attenuated in patients with coronary microvascular endothelial dysfunction, suggesting a role for RH- PAT as a noninvasive test to identify patients with this disorder.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2004-12-07 and is currently open access. It has received 905 citations till now. The article focuses on the topics: Reactive hyperemia & Endothelial dysfunction.read more
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Endothelial Function and Dysfunction Testing and Clinical Relevance
TL;DR: Current understanding of endothelial biology in health and disease, the strengths and weaknesses of current testing strategies, and their potential applications in clinical research and patient care are summarized.
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(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
Hagen Schroeter,Christian Heiss,Christian Heiss,Jan Balzer,Petra Kleinbongard,Carl L. Keen,Norman K. Hollenberg,Helmut Sies,Catherine Kwik-Uribe,Harold H. Schmitz,Malte Kelm +10 more
TL;DR: The data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa.
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The Assessment of Endothelial Function From Research Into Clinical Practice
Andreas J. Flammer,Todd J. Anderson,David S. Celermajer,Mark A. Creager,Mark A. Creager,John E. Deanfield,Peter Ganz,Naomi M. Hamburg,Thomas F. Lüscher,Michael Shechter,Stefano Taddei,Joseph A. Vita,Amir Lerman +12 more
TL;DR: The assessment of its vasodilator properties resulting from NO and other molecules may provide information on the integrity and function of the endothelium, and most, if not all, cardiovascular risk factors are associated with endothelial dysfunction, and risk factor modification leads to improvement in vascular function.
Journal ArticleDOI
Cardiovascular Disease in Women: Clinical Perspectives
TL;DR: This review provides current approaches to the evaluation and treatment of acute coronary syndromes that are more prevalent in women, including myocardial infarction associated with nonobstructive coronary arteries, spontaneous coronary artery dissection, and stress-induced cardiomyopathy.
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Cross-Sectional Relations of Digital Vascular Function to Cardiovascular Risk Factors in the Framingham Heart Study
Naomi M. Hamburg,Michelle J. Keyes,Martin G. Larson,Ramachandran S. Vasan,Renate B. Schnabel,Moira M. Pryde,Gary F. Mitchell,Jacob Sheffy,Joseph A. Vita,Emelia J. Benjamin +9 more
TL;DR: These findings support further investigations to define the clinical utility and predictive value of digital pulse amplitude and support the belief that digital vasodilator function is related to multiple traditional and metabolic cardiovascular risk factors.
References
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TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Endothelial Dysfunction A Marker of Atherosclerotic Risk
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Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Jassim Al Suwaidi,Shuichi Hamasaki,Stuart T. Higano,Rick A. Nishimura,David R. Holmes,Amir Lerman +5 more
TL;DR: Evaluating the outcome of patients with mild coronary artery disease on the basis of their endothelial function supports the concept that coronary endothelial dysfunction may play a role in the progression of coronary atherosclerosis.
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Close relation of endothelial function in the human coronary and peripheral circulations
Todd J. Anderson,Akimi Uehata,Marie D. Gerhard,Ian T. Meredith,Sarah Knab,Danielle Delagrange,Eric H. Lieberman,Peter Ganz,Mark A. Creager,Alan C. Yeung,Andrew P. Selwyn +10 more
TL;DR: This study demonstrated a close relation between coronary artery endothelium-dependent vasomotor responses to acetylcholine and flow-mediated vasodilation in the brachial artery, which may become a useful surrogate in assessing the predisposition to atherosclerosis in patients with cardiac risk factors.
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Assessment and treatment of endothelial dysfunction in humans
TL;DR: The endothelium plays a key role in vascular homeostasis through the release of a variety of autocrine and paracrine substances and is antiatherogenic because of effects that include inhibition of platelet aggregation and adhesion, smooth and hardening.