Piero Ruggenenti

TL;DR: In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandOLapril alone decreased the incidence of micro Albuminuria to a similar extent to that of placebo.

TL;DR: In non-diabetic nephropathies, ACE inhibition confers renoprotection even to patients with non-nephrotic proteinuria, and the rate of decline in GFR and the frequency of ESRF were much lower in stratum 1 than they had been instratum 2.

TL;DR: This article reviewed the abundant evidence in the literature that the process of reabsorption of filtered proteins activates the proximal tubular epithelium and gave rise to an inflammatory reaction that in most forms of glomerulonephritis consistently precede renal scarring.

TL;DR: Lower eGFR and more severe albuminuria independently predict mortality and ESRD among individuals selected for CKD, with the associations stronger for E SRD than for mortality.

TL;DR: In patients with non-diabetic proteinuric nephropathies receiving background ACE-inhibitor therapy, no additional benefit from further blood-pressure reduction by felodipine could be shown.