L
Lawrence J. Appel
Researcher at Johns Hopkins University
Publications - 647
Citations - 42833
Lawrence J. Appel is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Kidney disease & Blood pressure. The author has an hindex of 95, co-authored 592 publications receiving 36113 citations. Previous affiliations of Lawrence J. Appel include Beth Israel Deaconess Medical Center & Johns Hopkins University School of Medicine.
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Journal Article
Guidelines for the Primary Prevention of Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Larry B. Goldstein,Cheryl Bushnell,Robert J. Adams,Lawrence J. Appel,Lynne T. Braun,Seemant Chaturvedi,Mark A. Creager,Antonio Culebras,Robert H. Eckel,Robert G. Hart,Judith A. Hinchey,Virginia J. Howard,Edward C. Jauch,Steven R. Levine,James F. Meschia,Wesley S. Moore,Thomas A. Pearson +16 more
TL;DR: This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of a first stroke.
Journal ArticleDOI
Primary Prevention of Ischemic Stroke A Guideline From the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline.
Larry B. Goldstein,Robert J. Adams,Mark J. Alberts,Lawrence J. Appel,Lawrence M. Brass,Cheryl Bushnell,Antonio Culebras,Thomas J. DeGraba,Philip B. Gorelick,John R. Guyton,Robert G. Hart,George Howard,Margaret Kelly-Hayes,J.V. (Ian) Nixon,Ralph L. Sacco +14 more
TL;DR: In this paper, the authors provide an overview of the evidence on various established and potential stroke risk factors and provide recommendations for the reduction of stroke risk, and when appropriate, formulate recommendations based on standard American Heart Association criteria.
Journal ArticleDOI
Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association
Frank M. Sacks,Alice H. Lichtenstein,Jason H Y Wu,Lawrence J. Appel,Mark A. Creager,Penny M. Kris-Etherton,Michael I. Miller,Eric B. Rimm,Lawrence L. Rudel,Jennifer G. Robinson,Neil J. Stone,Linda Van Horn +11 more
TL;DR: Taking into consideration the totality of the scientific evidence, satisfying rigorous criteria for causality, it is concluded strongly that lowering intake of saturated fat and replacing it with uns saturated fats, especially polyunsaturated fats, will lower the incidence of CVD.
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Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality
Josef Coresh,Tanvir Chowdhury Turin,Kunihiro Matsushita,Yingying Sang,Shoshana H. Ballew,Lawrence J. Appel,Hisatomi Arima,Steven J. Chadban,Steven J. Chadban,Massimo Cirillo,Ognjenka Djurdjev,Jamie A. Green,Gunnar H. Heine,Lesley A. Inker,Fujiko Irie,Areef Ishani,Joachim H. Ix,Csaba P. Kovesdy,Csaba P. Kovesdy,Angharad Marks,Takayoshi Ohkubo,Takayoshi Ohkubo,Takayoshi Ohkubo,Varda Shalev,Anoop Shankar,Chi Pang Wen,Chi Pang Wen,Paul E. de Jong,Kunitoshi Iseki,Bénédicte Stengel,Ron T. Gansevoort,Andrew S. Levey +31 more
TL;DR: Declines in estimated GFR smaller than a doubling of serum creatinine concentration occurred more commonly and were strongly and consistently associated with the risk of ESRD and mortality, supporting consideration of lesser declines in Estimated GFR (such as a 30% reduction over 2 years) as an alternative end point for CKD progression.
Journal ArticleDOI
The Effects of Nonpharmacologic Interventions on Blood Pressure of Persons With High Normal Levels: Results of the Trials of Hypertension Prevention, Phase I
Paul K. Whelton,Lawrence J. Appel,Jeanne Charleston,Arlene Taylor Dalcin,Craig K. Ewart,Linda P. Fried,Delores Kaidy,Michael J. Klag,Shiriki K. Kumanyika,Lyn Steffen,W. Gordon Walker,Albert Oberman,Karen Counts,Heidi Hataway,James M. Raczynski,Neil Rappaport,Roland Weinsier,Nemat O. Borhani,Edmund Bernauer,Patricia A. Borhani,Carlos de la Cruz,Andrew Ertl,Doug Heustis,Marshall Lee,Wade Lovelace,Ellen O'Connor,Liz Peel,Carolyn Sugars,James O. Taylor,Beth Walker Corkery,Denis A. Evans,Mary Ellen Keough,Martha Clare Morris,Eleanor Pistorino,Frank M. Sacks,Mary Cameron,Sheila Corrigan,Nancy King Wright,William B. Applegate,Amy Brewer,Laretha Goodwin,Stephen T. Miller,Joseph T. Murphy,Judy Randle,Jay M. Sullivan,Norman L. Lasser,David M. Batey,Lee Dolan,Sheila Hamill,Pat Kennedy,Vera I. Lasser,Lewis H. Kuller,Arlene W. Caggiula,N. Carole Milas,Monica E. Yamamoto,Thomas M. Vogt,Merwyn R. Greenlick,Jack F. Hollis,Victor J. Stevens,Jerome D. Cohen,Mildred Mattfeldt-Beman,Connie Brinkmann,Katherine Roth,Lana Shepek,Charles H. Hennekens,Julie E. Buring,Nancy R. Cook,Ellie Danielson,Kim Eberlein,David Gordon,Patricia R. Hebert,Jean MacFadyen,Sherry L. Mayrent,Bernard Rosner,Suzanne Satterfield,Heather Tosteson,Martin Van Denburgh,Jeffrey A. Cutler,Erica Brittain,Marilyn Farrand,Peter G. Kaufmann,Ed Lakatos,Eva Obarzanek,John Belcher,Andrea Dommeyer,Ivan Mills,Peggy Neibling,Margo Woods,B.J. Kremen Goldman,Elaine Blethen +89 more
TL;DR: Weight reduction is the most effective of the strategies tested for reducing blood pressure in normotensive persons, and sodium reduction is also effective.