P
Pierre Lebrun
Researcher at University of Liège
Publications - 81
Citations - 2070
Pierre Lebrun is an academic researcher from University of Liège. The author has contributed to research in topics: Quality by Design & Bayesian probability. The author has an hindex of 27, co-authored 81 publications receiving 1774 citations.
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Journal ArticleDOI
Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
Benjamin De Backer,Benjamin Debrus,Pierre Lebrun,Laetitia Theunis,Nathalie Dubois,Lies Decock,Alain Verstraete,Philippe Hubert,Corinne Charlier +8 more
TL;DR: A simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material and was validated following an approach using accuracy profiles based on beta-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty.
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Design Spaces for analytical methods
TL;DR: This article aims to explain what an analytical method DS is, why it is useful for the robust development and optimization of analytical methods and how to build such a DS.
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Design space approach in the optimization of the spray-drying process.
Pierre Lebrun,Fabrice Krier,Jérôme Mantanus,Holger Grohganz,Mingshi Yang,Eric Rozet,Bruno Boulanger,Brigitte Evrard,Jukka Rantanen,Philippe Hubert +9 more
TL;DR: A predictive risk-based approach was set up in order to account for the uncertainties and correlations found in the process and in the derived critical quality attributes such as the yield, the moisture content, the inhalable fraction of powder, the compressibility index, and the Hausner ratio.
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Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space.
Benjamin Debrus,Pierre Lebrun,J. Mbinze Kindenge,J. Mbinze Kindenge,Frédéric Lecomte,Attilio Ceccato,Gabriel Caliaro,J. Mavar Tayey Mbay,Bruno Boulanger,Roland Djang’eing’a Marini,E. Rozet,Ph. Hubert +11 more
TL;DR: A dedicated method for the determination of three antimalarial compounds in a pharmaceutical formulation was optimized to demonstrate both the efficiency and flexibility of the methodology proposed in the present study.
Journal ArticleDOI
Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: Method development and validation
Jérôme Mantanus,Eric Ziemons,Pierre Lebrun,Eric Rozet,Régis Klinkenberg,Bruno Streel,Brigitte Evrard,Philippe Hubert +7 more
TL;DR: The present study confirmed that NIR spectroscopy could be used in the PAT concept as a non-invasive, non-destructive and fast technique for moisture content determination in pharmaceutical pellets.