P
Pierre Renard
Researcher at University of Caen Lower Normandy
Publications - 154
Citations - 4362
Pierre Renard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 34, co-authored 154 publications receiving 4150 citations. Previous affiliations of Pierre Renard include Blaise Pascal University & Paul Sabatier University.
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Journal ArticleDOI
Design of new anticancer drugs. II. Easy arynic access to benzocyclobutacarbazoles, a new family of antitumor agents
TL;DR: Tetrahydrobenzocyclobutacarbazoles with antitumoral properties were obtained either by arynic condensation of aryl halides with 3-carbazolone enolates or aryic cyclisation of halogenated arylimine enolated of 2-biphenylenones in the presence of the complex base NaNH2-tBuONa as mentioned in this paper.
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Design and Synthesis of Benzofuranic Derivatives as Potential Inhibitors of Hydroxyindole‐O‐methyltransferase
I. Le Picard,P. Depreux,I. Lesieur,Philippe Delagrange,Caroline Bennejean,Pierre Renard,P. Voisin +6 more
TL;DR: Of the compounds synthesized, N-[2-(7-naphth-1-yl)]phenylacetamide was the best inhibitor of hydroxyindole-O-methyltransferase (77% inhibition at a concentration of 10−4M).
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Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones.
Emmanuelle Braud,Muriel Duflos,Marie-Renée Nourrisson,Alain Tonnerre,Carine Picot,Guillaume Le Baut,Pierre Renard,Bruno Pfeiffer,Tucker Gordon +8 more
TL;DR: The synthesis and pharmacological evaluation of new 3-(imidazol-4(5)-ylmethylene)indolin-2-ones, analogues of SU-5416, are reported and the antiangiogenic activity of these compounds was evaluated in a three dimensional in vitro rat aortic ring assay.
Journal ArticleDOI
Complex bases promoted arynic cyclisations of halogenated imines or enamines: A regiochemical synthesis of indole derivatives
Catherine Caubere,Paul Caubere,Pierre Renard,Jean-Guy Bizot-Espiart,Brigitte Jamart-Grégoire +4 more
TL;DR: The complex base NaNH2-tBuONa allows the synthesis of indole derivatives by arynic cyclization of imines or enamines of chloroanilines as mentioned in this paper.
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Substituted oxygenated heterocycles and thio-analogues: synthesis and biological evaluation as melatonin ligands.
Isabelle Charton,Ahmed Mamai,Caroline Bennejean,Pierre Renard,Edward H. Howell,Beatrice Guardiola-Lemaitre,Philippe Delagrange,Peter J. Morgan,Marie-Claude Viaud,Gérald Guillaumet +9 more
TL;DR: A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands, showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb.